Poly( β-amino ester)–DNA complexes: Time-resolved fluorescence and cellular transfection studies

A large number of different polymers have been developed and studied for application as DNA carriers for non-viral gene delivery, but the DNA binding properties are not understood. This study describes the efficiency of nanoparticle formation by time-resolved fluorescence measurements for poly( β-am...

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Veröffentlicht in:	Journal of controlled release 2011-09, Vol.154 (2), p.171-176
Hauptverfasser:	Vuorimaa, Elina, Ketola, Tiia-Maaria, Green, Jordan J., Hanzlíková, Martina, Lemmetyinen, Helge, Langer, Robert, Anderson, Daniel G., Urtti, Arto, Yliperttula, Marjo
Format:	Artikel
Sprache:	eng
Schlagworte:	binding properties biodegradability Biological and medical sciences DNA DNA - genetics DNA - metabolism DNA binding DNA complexation esters fluorescence Gene delivery General pharmacology genes Medical sciences Nanoparticles Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly( β-amino esters) polymers Polymers - metabolism Protein Binding - physiology Spectrometry, Fluorescence - methods Time Factors Time-resolved fluorescence spectroscopy transfection Transfection - methods
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