Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption

Changes in intestinal absorption of nutrients are important aspects of the aging process. To address this issue, we investigated the impact of accelerated mitochondrial DNA mutations on the stem/progenitor cells in the crypts of Lieberkühn in mice homozygous for a mitochondrial DNA polymerase gamma...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2012-05, Vol.302 (9), p.G914-G924
Hauptverfasser:	Fox, Raymond G, Magness, Scott, Kujoth, Gregory C, Prolla, Tomas A, Maeda, Nobuyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Call for Papers Cell Count Cell Cycle - genetics Dietary Fats - metabolism DNA Polymerase gamma DNA-Directed DNA Polymerase - genetics Genotype & phenotype Intestinal Absorption - genetics Intestinal Absorption - physiology Lipids Male Mice Mice, Transgenic Mitochondrial DNA Mutation Mutation - genetics RNA Editing - genetics Rodents Stem cells Stem Cells - cytology Stem Cells - physiology
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