A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing

Several recent studies have provided evidence that LIN28, a cytoplasmic RNA-binding protein, inhibits the biogenesis of members of the let-7 microRNA family at the Dicer step in both mammals and Caenorhabditis elegans. However, the precise mechanism of inhibition is still poorly understood. Here we...

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Veröffentlicht in:	Biochemistry (Easton) 2011-09, Vol.50 (35), p.7514-7521
Hauptverfasser:	Lightfoot, Helen L, Bugaut, Anthony, Armisen, Javier, Lehrbach, Nicolas J, Miska, Eric A, Balasubramanian, Shankar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Caenorhabditis elegans - chemistry Caenorhabditis elegans - genetics Humans MicroRNAs - antagonists & inhibitors MicroRNAs - chemistry MicroRNAs - genetics Molecular Sequence Data Nucleic Acid Conformation Protein Binding - genetics Ribonuclease III - antagonists & inhibitors Ribonuclease III - genetics Ribonuclease III - metabolism RNA Precursors - antagonists & inhibitors RNA Precursors - chemistry RNA Precursors - genetics RNA Processing, Post-Transcriptional RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - physiology Structure-Activity Relationship
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