Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: Host–microbe interactions in intraocular infection
Bacterial endophthalmitis is a sight threatening infection of the interior structures of the eye. Incidence in the US has increased in recent years, which appears to be related to procedures being performed on an aging population. The advent of outpatient intravitreal therapy for management of age-r...
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| Veröffentlicht in: | Progress in retinal and eye research 2012-07, Vol.31 (4), p.316-331 |
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| container_title | Progress in retinal and eye research |
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| creator | Sadaka, Ama Durand, Marlene L. Gilmore, Michael S. |
| description | Bacterial endophthalmitis is a sight threatening infection of the interior structures of the eye. Incidence in the US has increased in recent years, which appears to be related to procedures being performed on an aging population. The advent of outpatient intravitreal therapy for management of age-related macular degeneration raises yet additional risks. Compounding the problem is the continuing progression of antibiotic resistance. Visual prognosis for endophthalmitis depends on the virulence of the causative organism, the severity of intraocular inflammation, and the timeliness of effective therapy. We review the current understanding of the pathogenesis of bacterial endophthalmitis, highlighting opportunities for the development of improved therapeutics and preventive strategies. |
| doi_str_mv | 10.1016/j.preteyeres.2012.03.004 |
| format | Article |
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Incidence in the US has increased in recent years, which appears to be related to procedures being performed on an aging population. The advent of outpatient intravitreal therapy for management of age-related macular degeneration raises yet additional risks. Compounding the problem is the continuing progression of antibiotic resistance. Visual prognosis for endophthalmitis depends on the virulence of the causative organism, the severity of intraocular inflammation, and the timeliness of effective therapy. We review the current understanding of the pathogenesis of bacterial endophthalmitis, highlighting opportunities for the development of improved therapeutics and preventive strategies.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacillus</subject><subject>Cataract Extraction - adverse effects</subject><subject>Coagulase-negative staphylococci</subject><subject>Endophthalmitis</subject><subject>Endophthalmitis - drug therapy</subject><subject>Endophthalmitis - microbiology</subject><subject>Enterococcus faecalis</subject><subject>Eye Infections, Bacterial - drug therapy</subject><subject>Eye Infections, Bacterial - microbiology</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Intravitreal Injections - adverse effects</subject><subject>Staphylococcus aureus</subject><subject>Steroids - therapeutic use</subject><subject>Streptococcus pneumoniae</subject><issn>1350-9462</issn><issn>1873-1635</issn><issn>1873-1635</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhiMEoqXwCshHLhvGduIkHJBoBRSpEhc4W44z2fUqiYPtrNRb3wGJB-RJmOyWAidOtjXf_894_ixjHHIOXL3e53PAhLcYMOYCuMhB5gDFo-yc15XccCXLx3SXJWyaQomz7FmMewBQ0JRPszMhSsHLCs6zH5fGJgzODAynzs-7tDPD6JKLzE0s7ZCZLTLfM7-k2SSHU6JCCubgUkBSERLM7DAyM3XMmmQCObK4hC3ZYnzDrn1MP---j84G3-KqxhVxfjr2OLp5uwwm0L3HY-V59qQ3Q8QX9-dF9vXD-y9X15ubzx8_Xb272diyKNNGlKZRPXRgeYloauiauqiR07tva1vVUkkJbV8oEAV9XvHatKZUTVFJU4leXmRvT77z0o7YWVyHGfQc3GjCrfbG6X8rk9vprT9oKRVXUJHBq3uD4L8tGJMeXbQ4DGZCv0RNcVVKCGIJrU8o7SHGgP1DGw4rp_Re_4lVr7FqkJpiJenLv8d8EP7OkYDLE4C0rIPDoKOlrCx2LtBGdefd_7v8ApLJv5A</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Sadaka, Ama</creator><creator>Durand, Marlene L.</creator><creator>Gilmore, Michael S.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120701</creationdate><title>Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: Host–microbe interactions in intraocular infection</title><author>Sadaka, Ama ; Durand, Marlene L. ; Gilmore, Michael S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-25a96f0d0c15eea80d9848e10c1fb8c7836330bf46024060618aba569473a72f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacillus</topic><topic>Cataract Extraction - adverse effects</topic><topic>Coagulase-negative staphylococci</topic><topic>Endophthalmitis</topic><topic>Endophthalmitis - drug therapy</topic><topic>Endophthalmitis - microbiology</topic><topic>Enterococcus faecalis</topic><topic>Eye Infections, Bacterial - drug therapy</topic><topic>Eye Infections, Bacterial - microbiology</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Intravitreal Injections - adverse effects</topic><topic>Staphylococcus aureus</topic><topic>Steroids - therapeutic use</topic><topic>Streptococcus pneumoniae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sadaka, Ama</creatorcontrib><creatorcontrib>Durand, Marlene L.</creatorcontrib><creatorcontrib>Gilmore, Michael S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Progress in retinal and eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sadaka, Ama</au><au>Durand, Marlene L.</au><au>Gilmore, Michael S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: Host–microbe interactions in intraocular infection</atitle><jtitle>Progress in retinal and eye research</jtitle><addtitle>Prog Retin Eye Res</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>31</volume><issue>4</issue><spage>316</spage><epage>331</epage><pages>316-331</pages><issn>1350-9462</issn><issn>1873-1635</issn><eissn>1873-1635</eissn><abstract>Bacterial endophthalmitis is a sight threatening infection of the interior structures of the eye. 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| fulltext | fulltext |
| identifier | ISSN: 1350-9462 |
| ispartof | Progress in retinal and eye research, 2012-07, Vol.31 (4), p.316-331 |
| issn | 1350-9462 1873-1635 1873-1635 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3361607 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anti-Bacterial Agents - therapeutic use Bacillus Cataract Extraction - adverse effects Coagulase-negative staphylococci Endophthalmitis Endophthalmitis - drug therapy Endophthalmitis - microbiology Enterococcus faecalis Eye Infections, Bacterial - drug therapy Eye Infections, Bacterial - microbiology Humans Immunosuppressive Agents - therapeutic use Intravitreal Injections - adverse effects Staphylococcus aureus Steroids - therapeutic use Streptococcus pneumoniae |
| title | Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: Host–microbe interactions in intraocular infection |
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