Invasive Escherichia coli vaccines expressing Brucella melitensis outer membrane proteins 31 or 16 or periplasmic protein BP26 confer protection in mice challenged with B. melitensis

Highlights ► Non-pathogenic invasive Escherichia coli used as a vaccine platform to mimic Brucella melitensis . ► Invasive E. coli expressing B. melitensis Omps induce IFN-γ and cytotoxic T cells. ► Vaccine platform expressing Omps induceantibodies and T cell proliferation. ► Invasive E. coli expres...

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Veröffentlicht in:	Vaccine 2012-06, Vol.30 (27), p.4017-4022
Hauptverfasser:	Gupta, V.K, Radhakrishnan, G, Harms, J, Splitter, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Allergy and Immunology Animals Antigen-presenting cells antigens Bacterial Load Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Brucella melitensis Brucella melitensis - genetics Brucella melitensis - immunology Brucella Omps31 Brucella Vaccine - administration & dosage Brucella Vaccine - genetics Brucella Vaccine - immunology Brucellosis Brucellosis - immunology Brucellosis - prevention & control cell-mediated immunity Cytokines - secretion Disease Models, Animal Domestic animals Drug Carriers - administration & dosage Economics Escherichia coli Escherichia coli - genetics Female genes Genetic Vectors hly gene Immune response Infection Invasive E. coli vaccine Leukocytes, Mononuclear - immunology Listeria monocytogenes Listeria monocytogenes - genetics Mice Mice, Inbred BALB C Omps16 outer membrane proteins Periplasmic protein BP26 Periplasmic Proteins - genetics Periplasmic Proteins - immunology Plasmids Pseudotuberculosis Spleen - immunology Spleen - microbiology Vaccines virulence Yersinia pseudotuberculosis Yersinia pseudotuberculosis - genetics
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container_title	Vaccine
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description	Highlights ► Non-pathogenic invasive Escherichia coli used as a vaccine platform to mimic Brucella melitensis . ► Invasive E. coli expressing B. melitensis Omps induce IFN-γ and cytotoxic T cells. ► Vaccine platform expressing Omps induceantibodies and T cell proliferation. ► Invasive E. coli expressing Omps protect against B. melitensis challenge.
doi_str_mv	10.1016/j.vaccine.2012.04.036
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genetics</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Brucella melitensis</subject><subject>Brucella melitensis - genetics</subject><subject>Brucella melitensis - immunology</subject><subject>Brucella Omps31</subject><subject>Brucella Vaccine - administration & dosage</subject><subject>Brucella Vaccine - genetics</subject><subject>Brucella Vaccine - immunology</subject><subject>Brucellosis</subject><subject>Brucellosis - immunology</subject><subject>Brucellosis - prevention & control</subject><subject>cell-mediated immunity</subject><subject>Cytokines - secretion</subject><subject>Disease Models, Animal</subject><subject>Domestic animals</subject><subject>Drug Carriers - administration & dosage</subject><subject>Economics</subject><subject>Escherichia coli</subject><subject>Escherichia coli - genetics</subject><subject>Female</subject><subject>genes</subject><subject>Genetic Vectors</subject><subject>hly gene</subject><subject>Immune response</subject><subject>Infection</subject><subject>Invasive E. coli vaccine</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Listeria monocytogenes</subject><subject>Listeria monocytogenes - genetics</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Omps16</subject><subject>outer membrane proteins</subject><subject>Periplasmic protein BP26</subject><subject>Periplasmic Proteins - genetics</subject><subject>Periplasmic Proteins - immunology</subject><subject>Plasmids</subject><subject>Pseudotuberculosis</subject><subject>Spleen - immunology</subject><subject>Spleen - microbiology</subject><subject>Vaccines</subject><subject>virulence</subject><subject>Yersinia pseudotuberculosis</subject><subject>Yersinia pseudotuberculosis - genetics</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAURiMEokPhEQAv2UzwX5xkU8RUBSpVAqlUYmc5zs2MB8dO7WSgL8bz4XSmVWEDmySyzz127v2y7CXBOcFEvN3mO6W1cZBTTGiOeY6ZeJQtSFWyJS1I9ThbYCr4khP87Sh7FuMWY1wwUj_NjigtuGAML7Jf526notkBOot6A8HojVFIe2vQwR8R_BwCxGjcGq3CpMFahXqwZgQXTUR-GiGkhb4JygEagh_BuIgYQT4gIubnkMyDVbE3-g5Aqy9UpJNcl6pv1_RovENpJ1GA9EZZC24NLfphxg1a5Q8OfZ496ZSN8OLwPs6uPpx9Pf20vPj88fz0_cVSF2U9LnlVVlxQrXBHKdactR2vlW4AOKOcdzXvSM0wSV9N1zRcVKwrcNUyVaom9YcdZyd77zA1PbQa3BiUlUMwvQo30isj_9xxZiPXficZE6SoRRK8OQiCv54gjrI38baFDvwUJcGMV7QSjPwHSsokpWK2FntUBx9jgO7-RgTPnJBbeRifnOMhMZcpHqnu1cPfua-6y0MCXu-BTnmp1sFEeXWZDAVOTWK4LBLxbk9AavvOQJBRG3AaWhPSBGXrzT8vcfKXQVvjjFb2O9xA3PopuDRTSWRMNfJyTvEcYkJTfkVJ2G8vm_A_</recordid><startdate>20120608</startdate><enddate>20120608</enddate><creator>Gupta, V.K</creator><creator>Radhakrishnan, G</creator><creator>Harms, J</creator><creator>Splitter, G</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20120608</creationdate><title>Invasive Escherichia coli vaccines expressing Brucella melitensis outer membrane proteins 31 or 16 or periplasmic protein BP26 confer protection in mice challenged with B. melitensis</title><author>Gupta, V.K ; Radhakrishnan, G ; Harms, J ; Splitter, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-4878462ca0f220c43df49acbee43244f94f193014f9bfbb4683f508d3a7ab3303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adjuvants</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antigen-presenting cells</topic><topic>antigens</topic><topic>Bacterial Load</topic><topic>Bacterial Outer Membrane Proteins - genetics</topic><topic>Bacterial Outer Membrane Proteins - immunology</topic><topic>Brucella melitensis</topic><topic>Brucella melitensis - genetics</topic><topic>Brucella melitensis - immunology</topic><topic>Brucella Omps31</topic><topic>Brucella Vaccine - administration & dosage</topic><topic>Brucella Vaccine - genetics</topic><topic>Brucella Vaccine - immunology</topic><topic>Brucellosis</topic><topic>Brucellosis - immunology</topic><topic>Brucellosis - prevention & control</topic><topic>cell-mediated immunity</topic><topic>Cytokines - secretion</topic><topic>Disease Models, Animal</topic><topic>Domestic animals</topic><topic>Drug Carriers - administration & dosage</topic><topic>Economics</topic><topic>Escherichia coli</topic><topic>Escherichia coli - genetics</topic><topic>Female</topic><topic>genes</topic><topic>Genetic Vectors</topic><topic>hly gene</topic><topic>Immune response</topic><topic>Infection</topic><topic>Invasive E. coli vaccine</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Listeria monocytogenes</topic><topic>Listeria monocytogenes - genetics</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Omps16</topic><topic>outer membrane proteins</topic><topic>Periplasmic protein BP26</topic><topic>Periplasmic Proteins - genetics</topic><topic>Periplasmic Proteins - immunology</topic><topic>Plasmids</topic><topic>Pseudotuberculosis</topic><topic>Spleen - immunology</topic><topic>Spleen - microbiology</topic><topic>Vaccines</topic><topic>virulence</topic><topic>Yersinia pseudotuberculosis</topic><topic>Yersinia pseudotuberculosis - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, V.K</creatorcontrib><creatorcontrib>Radhakrishnan, G</creatorcontrib><creatorcontrib>Harms, J</creatorcontrib><creatorcontrib>Splitter, G</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - 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subjects	Adjuvants Allergy and Immunology Animals Antigen-presenting cells antigens Bacterial Load Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Brucella melitensis Brucella melitensis - genetics Brucella melitensis - immunology Brucella Omps31 Brucella Vaccine - administration & dosage Brucella Vaccine - genetics Brucella Vaccine - immunology Brucellosis Brucellosis - immunology Brucellosis - prevention & control cell-mediated immunity Cytokines - secretion Disease Models, Animal Domestic animals Drug Carriers - administration & dosage Economics Escherichia coli Escherichia coli - genetics Female genes Genetic Vectors hly gene Immune response Infection Invasive E. coli vaccine Leukocytes, Mononuclear - immunology Listeria monocytogenes Listeria monocytogenes - genetics Mice Mice, Inbred BALB C Omps16 outer membrane proteins Periplasmic protein BP26 Periplasmic Proteins - genetics Periplasmic Proteins - immunology Plasmids Pseudotuberculosis Spleen - immunology Spleen - microbiology Vaccines virulence Yersinia pseudotuberculosis Yersinia pseudotuberculosis - genetics
title	Invasive Escherichia coli vaccines expressing Brucella melitensis outer membrane proteins 31 or 16 or periplasmic protein BP26 confer protection in mice challenged with B. melitensis
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