Invasive Escherichia coli vaccines expressing Brucella melitensis outer membrane proteins 31 or 16 or periplasmic protein BP26 confer protection in mice challenged with B. melitensis

Highlights ► Non-pathogenic invasive Escherichia coli used as a vaccine platform to mimic Brucella melitensis . ► Invasive E. coli expressing B. melitensis Omps induce IFN-γ and cytotoxic T cells. ► Vaccine platform expressing Omps induceantibodies and T cell proliferation. ► Invasive E. coli expres...

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Veröffentlicht in:	Vaccine 2012-06, Vol.30 (27), p.4017-4022
Hauptverfasser:	Gupta, V.K, Radhakrishnan, G, Harms, J, Splitter, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Allergy and Immunology Animals Antigen-presenting cells antigens Bacterial Load Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Brucella melitensis Brucella melitensis - genetics Brucella melitensis - immunology Brucella Omps31 Brucella Vaccine - administration & dosage Brucella Vaccine - genetics Brucella Vaccine - immunology Brucellosis Brucellosis - immunology Brucellosis - prevention & control cell-mediated immunity Cytokines - secretion Disease Models, Animal Domestic animals Drug Carriers - administration & dosage Economics Escherichia coli Escherichia coli - genetics Female genes Genetic Vectors hly gene Immune response Infection Invasive E. coli vaccine Leukocytes, Mononuclear - immunology Listeria monocytogenes Listeria monocytogenes - genetics Mice Mice, Inbred BALB C Omps16 outer membrane proteins Periplasmic protein BP26 Periplasmic Proteins - genetics Periplasmic Proteins - immunology Plasmids Pseudotuberculosis Spleen - immunology Spleen - microbiology Vaccines virulence Yersinia pseudotuberculosis Yersinia pseudotuberculosis - genetics
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Beschreibung
Zusammenfassung:	Highlights ► Non-pathogenic invasive Escherichia coli used as a vaccine platform to mimic Brucella melitensis . ► Invasive E. coli expressing B. melitensis Omps induce IFN-γ and cytotoxic T cells. ► Vaccine platform expressing Omps induceantibodies and T cell proliferation. ► Invasive E. coli expressing Omps protect against B. melitensis challenge.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.04.036