Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

Human melanocytic nevi (moles) are benign lesions harboring activated oncogenes, including BRAF. Although this oncogene initially acts mitogenically, eventually, oncogene-induced senescence (OIS) ensues. Nevi can infrequently progress to melanomas, but the mechanistic relationship with OIS is unclea...

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Veröffentlicht in:	Genes & development 2012-05, Vol.26 (10), p.1055-1069
Hauptverfasser:	Vredeveld, Liesbeth C W, Possik, Patricia A, Smit, Marjon A, Meissl, Katrin, Michaloglou, Chrysiis, Horlings, Hugo M, Ajouaou, Abderrahim, Kortman, Pim C, Dankort, David, McMahon, Martin, Mooi, Wolter J, Peeper, Daniel S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Cell Proliferation Cellular Senescence Cyclin-Dependent Kinase Inhibitor p15 - metabolism Enzyme Activation Fibroblasts - metabolism Fibroblasts - pathology Glutamic Acid - genetics Glutamic Acid - metabolism Humans Melanocytes - metabolism Melanocytes - pathology Melanoma - metabolism Melanoma - pathology Nevus - metabolism Nevus - pathology Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Research Paper Skin Neoplasms - metabolism Skin Neoplasms - pathology Valine - genetics Valine - metabolism
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