Keratin 8 phosphorylation regulates its transamidation and hepatocyte Mallory‐Denk body formation

Mallory‐Denk bodies (MDBs) are hepatocyte inclusions that are associated with poor liver disease prognosis. The intermediate filament protein keratin 8 (K8) and its cross‐linking by transglutaminase‐2 (TG2) are essential for MDB formation. K8 hyperphosphorylation occurs in association with liver inj...

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Veröffentlicht in:	The FASEB journal 2012-06, Vol.26 (6), p.2318-2326
Hauptverfasser:	Kwan, Raymond, Hanada, Shinichiro, Harada, Masaru, Strnad, Pavel, Li, Daniel H., Omary, M. Bishr
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Glutamine - metabolism GTP-Binding Proteins Hepatocytes - ultrastructure intermediate filaments Intermediate Filaments - metabolism Keratin-8 - genetics Keratin-8 - metabolism Liver Diseases - physiopathology Mallory Bodies - physiology Mice Mice, Transgenic Phosphorylation Research Communications steatohepatitis transglutaminase 2 Transglutaminases
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