Vesicular and conductive mechanisms of nucleotide release
Extracellular nucleotides and nucleosides promote a vast range of physiological responses, via activation of cell surface purinergic receptors. Virtually all tissues and cell types exhibit regulated release of ATP, which, in many cases, is accompanied by the release of uridine nucleotides. Given the...
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description | Extracellular nucleotides and nucleosides promote a vast range of physiological responses, via activation of cell surface purinergic receptors. Virtually all tissues and cell types exhibit regulated release of ATP, which, in many cases, is accompanied by the release of uridine nucleotides. Given the relevance of extracellular nucleotide/nucleoside-evoked responses, understanding how ATP and other nucleotides are released from cells is an important physiological question. By facilitating the entry of cytosolic nucleotides into the secretory pathway, recently identified vesicular nucleotide and nucleotide–sugar transporters contribute to the exocytotic release of ATP and UDP-sugars not only from endocrine/exocrine tissues, but also from cell types in which secretory granules have not been biochemically characterized. In addition, plasma membrane connexin hemichannels, pannexin channels, and less-well molecularly defined ATP conducting anion channels have been shown to contribute to the release of ATP (and UTP) under a variety of conditions. |
doi_str_mv | 10.1007/s11302-012-9304-9 |
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Virtually all tissues and cell types exhibit regulated release of ATP, which, in many cases, is accompanied by the release of uridine nucleotides. Given the relevance of extracellular nucleotide/nucleoside-evoked responses, understanding how ATP and other nucleotides are released from cells is an important physiological question. By facilitating the entry of cytosolic nucleotides into the secretory pathway, recently identified vesicular nucleotide and nucleotide–sugar transporters contribute to the exocytotic release of ATP and UDP-sugars not only from endocrine/exocrine tissues, but also from cell types in which secretory granules have not been biochemically characterized. In addition, plasma membrane connexin hemichannels, pannexin channels, and less-well molecularly defined ATP conducting anion channels have been shown to contribute to the release of ATP (and UTP) under a variety of conditions.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Adenosine Triphosphate - physiology</subject><subject>Animals</subject><subject>Anion channels</subject><subject>ATP</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cell activation</subject><subject>Cell surface</subject><subject>Connexins</subject><subject>Connexins - metabolism</subject><subject>Connexins - physiology</subject><subject>Cytoplasmic Vesicles - metabolism</subject><subject>Cytoplasmic Vesicles - physiology</subject><subject>Exocytosis</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Neurosciences</subject><subject>nucleosides</subject><subject>Nucleotides</subject><subject>Nucleotides - metabolism</subject><subject>Nucleotides - physiology</subject><subject>Pharmacology/Toxicology</subject><subject>Plasma membranes</subject><subject>Purine receptors</subject><subject>Receptors, Purinergic - physiology</subject><subject>Review</subject><subject>Secretory vesicles</subject><subject>Signal transduction</subject><subject>Signal Transduction - physiology</subject><subject>TRPV Cation Channels - physiology</subject><subject>Uridine</subject><subject>Uridine Diphosphate - metabolism</subject><subject>Uridine Diphosphate - physiology</subject><issn>1573-9538</issn><issn>1573-9546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1LxDAQhoMofqz-AC_So5dqPtqkuQgifoHgRb2GaTrZrbSJJq3gv7fLrotexEsSmCcvM_MQcszoGaNUnSfGBOU5ZTzXgha53iL7rFQi12UhtzdvUe2Rg5ReKS0LLvQu2eO85JVUep_oF0ytHTuIGfgms8E3ox3aD8x6tAvwbepTFlzmR9thGNoGs4gdQsJDsuOgS3i0vmfk-eb66eouf3i8vb-6fMhtwdWQ18JRK7HUJVheNyBrJ7mqBZQWBFdUFCisU5UCNxEOKscrUACucroobCNm5GKV-zbWPTYW_RChM2-x7SF-mgCt-V3x7cLMw4cRQlKqxRRwug6I4X3ENJi-TRa7DjyGMRlGpeaUK8n_gTIpFdXlEmUr1MaQUkS36YhRs7RjVnbMZMcs7UzHjJz8HGXz41vHBPAVkKaSn2M0r2GMflrvH6lfAQKcMg</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Lazarowski, Eduardo R.</creator><general>Springer Netherlands</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope><scope>5PM</scope></search><sort><creationdate>20120901</creationdate><title>Vesicular and conductive mechanisms of nucleotide release</title><author>Lazarowski, Eduardo R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-b3f0c6e595ac2bda6bf627b3a5ca327034e3cf787af5acfa8f28a7aaf8f944cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adenosine Triphosphate - 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Virtually all tissues and cell types exhibit regulated release of ATP, which, in many cases, is accompanied by the release of uridine nucleotides. Given the relevance of extracellular nucleotide/nucleoside-evoked responses, understanding how ATP and other nucleotides are released from cells is an important physiological question. By facilitating the entry of cytosolic nucleotides into the secretory pathway, recently identified vesicular nucleotide and nucleotide–sugar transporters contribute to the exocytotic release of ATP and UDP-sugars not only from endocrine/exocrine tissues, but also from cell types in which secretory granules have not been biochemically characterized. 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subjects | Adenosine Triphosphate - metabolism Adenosine Triphosphate - physiology Animals Anion channels ATP Biomedical and Life Sciences Biomedicine Cancer Research Cell activation Cell surface Connexins Connexins - metabolism Connexins - physiology Cytoplasmic Vesicles - metabolism Cytoplasmic Vesicles - physiology Exocytosis Human Physiology Humans Neurosciences nucleosides Nucleotides Nucleotides - metabolism Nucleotides - physiology Pharmacology/Toxicology Plasma membranes Purine receptors Receptors, Purinergic - physiology Review Secretory vesicles Signal transduction Signal Transduction - physiology TRPV Cation Channels - physiology Uridine Uridine Diphosphate - metabolism Uridine Diphosphate - physiology |
title | Vesicular and conductive mechanisms of nucleotide release |
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