Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation

We assessed the safety and efficacy of combined intravenous and aerosolized antioxidant administration to attenuate chlorine gas-induced airway alterations when administered after exposure. Adult male Sprague-Dawley rats were exposed to air or 400 parts per million (ppm) chlorine (a concentration li...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2012-05, Vol.46 (5), p.599-606
Hauptverfasser:	Fanucchi, Michelle V, Bracher, Andreas, Doran, Stephen F, Squadrito, Giuseppe L, Fernandez, Solana, Postlethwait, Edward M, Bowen, Larry, Matalon, Sadis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Antioxidants - therapeutic use Ascorbic Acid - metabolism Bronchi - drug effects Bronchi - pathology Bronchial Provocation Tests Chlorine - administration & dosage Chlorine - toxicity Glutathione - metabolism Hyperplasia - prevention & control Inhalation Exposure Lung - pathology Male Rats Rats, Sprague-Dawley Trachea - drug effects Trachea - pathology
Online-Zugang:	Volltext
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