Is laser photocoagulation still effective in diabetic macular edema? Assessment with optical coherence tomography in Nepal
AIM: To find out the outcome of laser photocoagulation in clinically significant macular edema (CSME) by optical coherence tomography (OCT). · METHODS: It was a prospective, non-controlled, case series study enrolling 81 eyes of 64 patients with CSME between August 2008 and January 2010. All patient...
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description | AIM: To find out the outcome of laser photocoagulation in clinically significant macular edema (CSME) by optical coherence tomography (OCT). · METHODS: It was a prospective, non-controlled, case series study enrolling 81 eyes of 64 patients with CSME between August 2008 and January 2010. All patients received modified grid photocoagulation with frequency doubled Nd: YAG laser. Each patient was evaluated in terms of best-corrected visual acuity (BCVA) and regression or progression of maculopathy after laser therapy at 1, 3 and 6 months. Spearman’s correlation test was used to show the correlation between BCVA and total macular volume (TMV). Analysis of variance (ANOVA) was used to compare among groups and independent t-test was used to compare in each group. · RESULTS: There is high correlation between BCVA and TMV (P ≤0.001). BCVA improved in 50.6%, remained static in 39.5 % and deteriorated in 9.9% patients after 6 month of treatment. The Baseline TMV (mean and SD) were 9.26±1.83, 10.4±2.38, 11.5±3.05, 8.89±0.75 and 9.47±1.98 mm3 for different OCT patterns, ST (sponge like thickening), CMO (cystoid macular edema), SFD (subfoveal detachment), VMIA (Vitreo macular interface abnormality) and average TMV respectively (P =0.04). After 6 months of laser treatment, the mean TMV decreased from 9.47±1.98mm3 to 8.77±1.31mm3(P =0.01). In ST there was significant decrease in TMV, P =0.01, Further within these groups at 6 months, they were significantly different, P =0.01. · CONCLUSION: OCT showed the different morphological variant of CSME while the response of treatment is different. TMV decreased the most and hence showed the improvement in vision after 6 months of laser treatment. In the era of Anti vascular endothelial growth factors (VEGFs), efficacy of laser seems to be in shadow but it is still first line of treatment in developing nation like Nepal where antiVEGFs may not be easily available and affordable. |
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Assessment with optical coherence tomography in Nepal</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><creator>Shrestha, Arjun ; Khadka, Deepak ; Karmacharya, Angira ; Maharjan, Nhukesh ; Shrestha, Anand ; Thapa, Raba ; Poudyal, Govinda</creator><creatorcontrib>Shrestha, Arjun ; Khadka, Deepak ; Karmacharya, Angira ; Maharjan, Nhukesh ; Shrestha, Anand ; Thapa, Raba ; Poudyal, Govinda</creatorcontrib><description>AIM: To find out the outcome of laser photocoagulation in clinically significant macular edema (CSME) by optical coherence tomography (OCT). · METHODS: It was a prospective, non-controlled, case series study enrolling 81 eyes of 64 patients with CSME between August 2008 and January 2010. All patients received modified grid photocoagulation with frequency doubled Nd: YAG laser. Each patient was evaluated in terms of best-corrected visual acuity (BCVA) and regression or progression of maculopathy after laser therapy at 1, 3 and 6 months. Spearman’s correlation test was used to show the correlation between BCVA and total macular volume (TMV). Analysis of variance (ANOVA) was used to compare among groups and independent t-test was used to compare in each group. · RESULTS: There is high correlation between BCVA and TMV (P ≤0.001). BCVA improved in 50.6%, remained static in 39.5 % and deteriorated in 9.9% patients after 6 month of treatment. The Baseline TMV (mean and SD) were 9.26±1.83, 10.4±2.38, 11.5±3.05, 8.89±0.75 and 9.47±1.98 mm3 for different OCT patterns, ST (sponge like thickening), CMO (cystoid macular edema), SFD (subfoveal detachment), VMIA (Vitreo macular interface abnormality) and average TMV respectively (P =0.04). After 6 months of laser treatment, the mean TMV decreased from 9.47±1.98mm3 to 8.77±1.31mm3(P =0.01). In ST there was significant decrease in TMV, P =0.01, Further within these groups at 6 months, they were significantly different, P =0.01. · CONCLUSION: OCT showed the different morphological variant of CSME while the response of treatment is different. TMV decreased the most and hence showed the improvement in vision after 6 months of laser treatment. In the era of Anti vascular endothelial growth factors (VEGFs), efficacy of laser seems to be in shadow but it is still first line of treatment in developing nation like Nepal where antiVEGFs may not be easily available and affordable.</description><identifier>ISSN: 2222-3959</identifier><identifier>EISSN: 2227-4898</identifier><identifier>DOI: 10.3980/j.issn.2222-3959.2012.02.20</identifier><identifier>PMID: 22762054</identifier><language>eng</language><publisher>China: International Journal of Ophthalmology Press</publisher><subject>Clinical Research ; Clinically ; coherence ; edema ; Grid ; laser ; macular ; Optical ; photocoagulation ; significant ; tomography ; Total ; volume</subject><ispartof>International journal of ophthalmology, 2012, Vol.5 (2), p.217-221</ispartof><rights>International Journal of Ophthalmology Press 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/60944X/60944X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359042/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359042/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22762054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shrestha, Arjun</creatorcontrib><creatorcontrib>Khadka, Deepak</creatorcontrib><creatorcontrib>Karmacharya, Angira</creatorcontrib><creatorcontrib>Maharjan, Nhukesh</creatorcontrib><creatorcontrib>Shrestha, Anand</creatorcontrib><creatorcontrib>Thapa, Raba</creatorcontrib><creatorcontrib>Poudyal, Govinda</creatorcontrib><title>Is laser photocoagulation still effective in diabetic macular edema? Assessment with optical coherence tomography in Nepal</title><title>International journal of ophthalmology</title><addtitle>International Journal of Ophthalmology</addtitle><description>AIM: To find out the outcome of laser photocoagulation in clinically significant macular edema (CSME) by optical coherence tomography (OCT). · METHODS: It was a prospective, non-controlled, case series study enrolling 81 eyes of 64 patients with CSME between August 2008 and January 2010. All patients received modified grid photocoagulation with frequency doubled Nd: YAG laser. Each patient was evaluated in terms of best-corrected visual acuity (BCVA) and regression or progression of maculopathy after laser therapy at 1, 3 and 6 months. Spearman’s correlation test was used to show the correlation between BCVA and total macular volume (TMV). Analysis of variance (ANOVA) was used to compare among groups and independent t-test was used to compare in each group. · RESULTS: There is high correlation between BCVA and TMV (P ≤0.001). BCVA improved in 50.6%, remained static in 39.5 % and deteriorated in 9.9% patients after 6 month of treatment. The Baseline TMV (mean and SD) were 9.26±1.83, 10.4±2.38, 11.5±3.05, 8.89±0.75 and 9.47±1.98 mm3 for different OCT patterns, ST (sponge like thickening), CMO (cystoid macular edema), SFD (subfoveal detachment), VMIA (Vitreo macular interface abnormality) and average TMV respectively (P =0.04). After 6 months of laser treatment, the mean TMV decreased from 9.47±1.98mm3 to 8.77±1.31mm3(P =0.01). In ST there was significant decrease in TMV, P =0.01, Further within these groups at 6 months, they were significantly different, P =0.01. · CONCLUSION: OCT showed the different morphological variant of CSME while the response of treatment is different. TMV decreased the most and hence showed the improvement in vision after 6 months of laser treatment. In the era of Anti vascular endothelial growth factors (VEGFs), efficacy of laser seems to be in shadow but it is still first line of treatment in developing nation like Nepal where antiVEGFs may not be easily available and affordable.</description><subject>Clinical Research</subject><subject>Clinically</subject><subject>coherence</subject><subject>edema</subject><subject>Grid</subject><subject>laser</subject><subject>macular</subject><subject>Optical</subject><subject>photocoagulation</subject><subject>significant</subject><subject>tomography</subject><subject>Total</subject><subject>volume</subject><issn>2222-3959</issn><issn>2227-4898</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpVkMtu1jAQhS0EolXpKyBL3bBJ8DWJN6Cq4lKpgg2so4kzSVw5dhr7LypPj-EvFZzNjGY-nTMaQi44q6Xp2Nvb2qUUalFUSaNNLRgXNROlPiOnZdpWqjPd8z_9ETkh5yndsqJGM87US3JSsEYwrU7Jz-tEPSTc6bbEHG2E-eAhuxhoys57itOENrt7pC7Q0cGA2Vm6gi3YTnHEFd7Ty5QwpRVDpj9cXmjcCgSe2rjgjsEizXGN8w7b8vDb5wtu4F-RFxP4hOeP9Yx8__jh29Xn6ubrp-ury5vKCqNyNY5KTZNlFpjGsR0bLZpBKWh4N1oNpuPKDLblZlJlbblFiQKBd9IqaActz8i7o-92GFYcbblyB99vu1thf-gjuP7_TXBLP8f7XkptmBLF4M2jwR7vDphyv7pk0XsIGA-p50xILUXXyYK-_jfrKeTvwwtwcQTsEsN858L8xHDGJJOGyVb-AsUclkA</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Shrestha, Arjun</creator><creator>Khadka, Deepak</creator><creator>Karmacharya, Angira</creator><creator>Maharjan, Nhukesh</creator><creator>Shrestha, Anand</creator><creator>Thapa, Raba</creator><creator>Poudyal, Govinda</creator><general>International Journal of Ophthalmology Press</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2012</creationdate><title>Is laser photocoagulation still effective in diabetic macular edema? Assessment with optical coherence tomography in Nepal</title><author>Shrestha, Arjun ; Khadka, Deepak ; Karmacharya, Angira ; Maharjan, Nhukesh ; Shrestha, Anand ; Thapa, Raba ; Poudyal, Govinda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c294t-dd44ffc0ca05ed7d6526b44a618dc5a98149bc719f4ed7c1ce3e2ea183c4a7b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Clinical Research</topic><topic>Clinically</topic><topic>coherence</topic><topic>edema</topic><topic>Grid</topic><topic>laser</topic><topic>macular</topic><topic>Optical</topic><topic>photocoagulation</topic><topic>significant</topic><topic>tomography</topic><topic>Total</topic><topic>volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shrestha, Arjun</creatorcontrib><creatorcontrib>Khadka, Deepak</creatorcontrib><creatorcontrib>Karmacharya, Angira</creatorcontrib><creatorcontrib>Maharjan, Nhukesh</creatorcontrib><creatorcontrib>Shrestha, Anand</creatorcontrib><creatorcontrib>Thapa, Raba</creatorcontrib><creatorcontrib>Poudyal, Govinda</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shrestha, Arjun</au><au>Khadka, Deepak</au><au>Karmacharya, Angira</au><au>Maharjan, Nhukesh</au><au>Shrestha, Anand</au><au>Thapa, Raba</au><au>Poudyal, Govinda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is laser photocoagulation still effective in diabetic macular edema? Assessment with optical coherence tomography in Nepal</atitle><jtitle>International journal of ophthalmology</jtitle><addtitle>International Journal of Ophthalmology</addtitle><date>2012</date><risdate>2012</risdate><volume>5</volume><issue>2</issue><spage>217</spage><epage>221</epage><pages>217-221</pages><issn>2222-3959</issn><eissn>2227-4898</eissn><abstract>AIM: To find out the outcome of laser photocoagulation in clinically significant macular edema (CSME) by optical coherence tomography (OCT). · METHODS: It was a prospective, non-controlled, case series study enrolling 81 eyes of 64 patients with CSME between August 2008 and January 2010. All patients received modified grid photocoagulation with frequency doubled Nd: YAG laser. Each patient was evaluated in terms of best-corrected visual acuity (BCVA) and regression or progression of maculopathy after laser therapy at 1, 3 and 6 months. Spearman’s correlation test was used to show the correlation between BCVA and total macular volume (TMV). Analysis of variance (ANOVA) was used to compare among groups and independent t-test was used to compare in each group. · RESULTS: There is high correlation between BCVA and TMV (P ≤0.001). BCVA improved in 50.6%, remained static in 39.5 % and deteriorated in 9.9% patients after 6 month of treatment. The Baseline TMV (mean and SD) were 9.26±1.83, 10.4±2.38, 11.5±3.05, 8.89±0.75 and 9.47±1.98 mm3 for different OCT patterns, ST (sponge like thickening), CMO (cystoid macular edema), SFD (subfoveal detachment), VMIA (Vitreo macular interface abnormality) and average TMV respectively (P =0.04). After 6 months of laser treatment, the mean TMV decreased from 9.47±1.98mm3 to 8.77±1.31mm3(P =0.01). In ST there was significant decrease in TMV, P =0.01, Further within these groups at 6 months, they were significantly different, P =0.01. · CONCLUSION: OCT showed the different morphological variant of CSME while the response of treatment is different. TMV decreased the most and hence showed the improvement in vision after 6 months of laser treatment. In the era of Anti vascular endothelial growth factors (VEGFs), efficacy of laser seems to be in shadow but it is still first line of treatment in developing nation like Nepal where antiVEGFs may not be easily available and affordable.</abstract><cop>China</cop><pub>International Journal of Ophthalmology Press</pub><pmid>22762054</pmid><doi>10.3980/j.issn.2222-3959.2012.02.20</doi><tpages>5</tpages></addata></record> |
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subjects | Clinical Research Clinically coherence edema Grid laser macular Optical photocoagulation significant tomography Total volume |
title | Is laser photocoagulation still effective in diabetic macular edema? Assessment with optical coherence tomography in Nepal |
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