Sclerostin is a locally acting regulator of late‐osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE‐ASARM‐dependent mechanism

The identity of the cell type responsive to sclerostin, a negative regulator of bone mass, is unknown. Since sclerostin is expressed in vivo by mineral‐embedded osteocytes, we tested the hypothesis that sclerostin would regulate the behavior of cells actively involved in mineralization in adult bone...

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Veröffentlicht in:	Journal of bone and mineral research 2011-07, Vol.26 (7), p.1425-1436
Hauptverfasser:	Atkins, Gerald J, Rowe, Peter S, Lim, Hui P, Welldon, Katie J, Ormsby, Renee, Wijenayaka, Asiri R, Zelenchuk, Lesya, Evdokiou, Andreas, Findlay, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - pharmacology ASARM Biological and medical sciences Bone Morphogenetic Proteins - metabolism Bone Morphogenetic Proteins - pharmacology Calcification, Physiologic - drug effects Calcification, Physiologic - genetics Cell Differentiation - drug effects Cell Differentiation - genetics Cells, Cultured Extracellular Matrix Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Genetic Markers Glycoproteins - metabolism Humans Hypophosphatemia - metabolism Hypophosphatemia - pathology MEPE Mice Models, Biological Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteocyte Osteocytes - cytology Osteocytes - drug effects Osteocytes - metabolism PHEX Phosphate Regulating Neutral Endopeptidase - metabolism Phosphoproteins - metabolism Recombinant Proteins - pharmacology Sclerostin Skeleton and joints Sost Vertebrates: osteoarticular system, musculoskeletal system
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