Angiotensin II- and Salt-Induced Kidney Injury through Rac1-Mediated Mineralocorticoid Receptor Activation

Experiments with hyperaldosteronemic animals suggest that, despite lowering plasma aldosterone, salt worsens renal injury by paradoxical activation of the mineralocorticoid receptor (MR). Salt and aldosterone synergistically contribute to renal impairment through Rac1-mediated activation of the MR,...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2012-06, Vol.23 (6), p.997-1007
Hauptverfasser:	KAWARAZAKI, Wakako, NAGASE, Miki, YOSHIDA, Shigetaka, TAKEUCHI, Maki, ISHIZAWA, Kenichi, AYUZAWA, Nobuhiro, UEDA, Kohei, FUJITA, Toshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute Kidney Injury - physiopathology Adrenalectomy - methods Aldosterone - blood Aldosterone - metabolism Analysis of Variance Angiotensin II - adverse effects Angiotensin II - pharmacology Animals Basic Research Biological and medical sciences Blotting, Western Disease Models, Animal Immunohistochemistry Male Medical sciences Mice Mice, Inbred Strains Nephrology. Urinary tract diseases rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Random Allocation Real-Time Polymerase Chain Reaction - methods Receptors, Mineralocorticoid - metabolism Signal Transduction Sodium Chloride, Dietary - adverse effects Sodium Chloride, Dietary - pharmacology Spironolactone - analogs & derivatives Spironolactone - pharmacology Statistics, Nonparametric
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