Pesticide exposure and amyotrophic lateral sclerosis
► Pesticide exposure and amyotrophic lateral sclerosis. ► In a meta-analysis of 8 studies, ALS was associated with general pesticide exposure. ► In an agricultural cohort, ALS was associated with organochlorine insecticides. ► Specific pesticides associated with ALS were aldrin, dieldrin, DDT, and t...
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| Veröffentlicht in: | Neurotoxicology (Park Forest South) 2012-06, Vol.33 (3), p.457-462 |
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| creator | Kamel, Freya Umbach, David M. Bedlack, Richard S. Richards, Marie Watson, Mary Alavanja, Michael C.R. Blair, Aaron Hoppin, Jane A. Schmidt, Silke Sandler, Dale P. |
| description | ► Pesticide exposure and amyotrophic lateral sclerosis. ► In a meta-analysis of 8 studies, ALS was associated with general pesticide exposure. ► In an agricultural cohort, ALS was associated with organochlorine insecticides. ► Specific pesticides associated with ALS were aldrin, dieldrin, DDT, and toxaphene.
Our objectives were to summarize literature on the association of amyotrophic lateral sclerosis (ALS) with pesticides as a group and to evaluate associations of ALS with specific pesticides. We conducted a meta-analysis of published studies of ALS and pesticides as a group and investigated the association of ALS with specific pesticides, using data from the Agricultural Health Study (AHS), a cohort including 84,739 private pesticide applicators and spouses. AHS participants provided information on pesticide use at enrollment in 1993–1997. In mortality data collected through February 2010, ALS was recorded on death certificates of 41 individuals whom we compared to the remaining cohort (controls), using unconditional logistic regression adjusted for age and gender to calculate odds ratios (ORs) and 95% confidence intervals. In the meta-analysis, ALS was associated with use of pesticides as a group (1.9, 1.1–3.1). In the AHS, ALS was not associated with pesticides as a group, but was associated with use of organochlorine insecticides (OCs) (1.6, 0.8–3.5), pyrethroids (1.4, 0.6–3.4), herbicides (1.6, 0.7–3.7), and fumigants (1.8, 0.8–3.9). ORs were elevated forever use of the specific OCs aldrin (2.1, 0.8–5.1), dieldrin (2.6, 0.9–7.3), DDT (2.1, 0.9–5.0), and toxaphene (2.0, 0.8–4.9). None of these associations was statistically significant. Similar results were observed in an analysis restricted to men. In conclusion, the meta-analysis suggests that ALS risk is associated with use of pesticides as a group, and our analysis of AHS data points to OC use in particular. The latter results are novel but based on a small number of cases and require replication in other populations. |
| doi_str_mv | 10.1016/j.neuro.2012.04.001 |
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Our objectives were to summarize literature on the association of amyotrophic lateral sclerosis (ALS) with pesticides as a group and to evaluate associations of ALS with specific pesticides. We conducted a meta-analysis of published studies of ALS and pesticides as a group and investigated the association of ALS with specific pesticides, using data from the Agricultural Health Study (AHS), a cohort including 84,739 private pesticide applicators and spouses. AHS participants provided information on pesticide use at enrollment in 1993–1997. In mortality data collected through February 2010, ALS was recorded on death certificates of 41 individuals whom we compared to the remaining cohort (controls), using unconditional logistic regression adjusted for age and gender to calculate odds ratios (ORs) and 95% confidence intervals. In the meta-analysis, ALS was associated with use of pesticides as a group (1.9, 1.1–3.1). In the AHS, ALS was not associated with pesticides as a group, but was associated with use of organochlorine insecticides (OCs) (1.6, 0.8–3.5), pyrethroids (1.4, 0.6–3.4), herbicides (1.6, 0.7–3.7), and fumigants (1.8, 0.8–3.9). ORs were elevated forever use of the specific OCs aldrin (2.1, 0.8–5.1), dieldrin (2.6, 0.9–7.3), DDT (2.1, 0.9–5.0), and toxaphene (2.0, 0.8–4.9). None of these associations was statistically significant. Similar results were observed in an analysis restricted to men. In conclusion, the meta-analysis suggests that ALS risk is associated with use of pesticides as a group, and our analysis of AHS data points to OC use in particular. The latter results are novel but based on a small number of cases and require replication in other populations.</description><identifier>ISSN: 0161-813X</identifier><identifier>EISSN: 1872-9711</identifier><identifier>DOI: 10.1016/j.neuro.2012.04.001</identifier><identifier>PMID: 22521219</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Age Factors ; Aged ; Agricultural Workers' Diseases - chemically induced ; Agricultural Workers' Diseases - mortality ; Agriculture ; Aldrin ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - chemically induced ; Amyotrophic Lateral Sclerosis - mortality ; Biological and medical sciences ; Cerebrospinal fluid. Meninges. Spinal cord ; Cohort study ; Data processing ; DDT ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dieldrin ; Female ; Fumigants ; Herbicides ; Humans ; Hydrocarbons, Chlorinated - adverse effects ; Insecticides ; Logistic Models ; Male ; Medical sciences ; Meta-analysis ; Middle Aged ; Mortality ; Motor neuron disease ; Nervous system (semeiology, syndromes) ; Neurology ; Occupational Exposure ; Odds Ratio ; Organochlorine compounds ; Organochlorine insecticides ; Pesticides ; Pesticides - adverse effects ; Pesticides, fertilizers and other agrochemicals toxicology ; Pyrethroids ; Replication ; Reviews ; Risk Assessment ; Risk Factors ; Sex Factors ; Spouses ; Statistical analysis ; Toxaphene ; Toxicology</subject><ispartof>Neurotoxicology (Park Forest South), 2012-06, Vol.33 (3), p.457-462</ispartof><rights>2012</rights><rights>2015 INIST-CNRS</rights><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-d79a059334032d9d9f1f9edf09bb8bc2f377bcdebce5a5ba548b945692d3791b3</citedby><cites>FETCH-LOGICAL-c522t-d79a059334032d9d9f1f9edf09bb8bc2f377bcdebce5a5ba548b945692d3791b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0161813X12000770$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26011778$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22521219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamel, Freya</creatorcontrib><creatorcontrib>Umbach, David M.</creatorcontrib><creatorcontrib>Bedlack, Richard S.</creatorcontrib><creatorcontrib>Richards, Marie</creatorcontrib><creatorcontrib>Watson, Mary</creatorcontrib><creatorcontrib>Alavanja, Michael C.R.</creatorcontrib><creatorcontrib>Blair, Aaron</creatorcontrib><creatorcontrib>Hoppin, Jane A.</creatorcontrib><creatorcontrib>Schmidt, Silke</creatorcontrib><creatorcontrib>Sandler, Dale P.</creatorcontrib><title>Pesticide exposure and amyotrophic lateral sclerosis</title><title>Neurotoxicology (Park Forest South)</title><addtitle>Neurotoxicology</addtitle><description>► Pesticide exposure and amyotrophic lateral sclerosis. ► In a meta-analysis of 8 studies, ALS was associated with general pesticide exposure. ► In an agricultural cohort, ALS was associated with organochlorine insecticides. ► Specific pesticides associated with ALS were aldrin, dieldrin, DDT, and toxaphene.
Our objectives were to summarize literature on the association of amyotrophic lateral sclerosis (ALS) with pesticides as a group and to evaluate associations of ALS with specific pesticides. We conducted a meta-analysis of published studies of ALS and pesticides as a group and investigated the association of ALS with specific pesticides, using data from the Agricultural Health Study (AHS), a cohort including 84,739 private pesticide applicators and spouses. AHS participants provided information on pesticide use at enrollment in 1993–1997. In mortality data collected through February 2010, ALS was recorded on death certificates of 41 individuals whom we compared to the remaining cohort (controls), using unconditional logistic regression adjusted for age and gender to calculate odds ratios (ORs) and 95% confidence intervals. In the meta-analysis, ALS was associated with use of pesticides as a group (1.9, 1.1–3.1). In the AHS, ALS was not associated with pesticides as a group, but was associated with use of organochlorine insecticides (OCs) (1.6, 0.8–3.5), pyrethroids (1.4, 0.6–3.4), herbicides (1.6, 0.7–3.7), and fumigants (1.8, 0.8–3.9). ORs were elevated forever use of the specific OCs aldrin (2.1, 0.8–5.1), dieldrin (2.6, 0.9–7.3), DDT (2.1, 0.9–5.0), and toxaphene (2.0, 0.8–4.9). None of these associations was statistically significant. Similar results were observed in an analysis restricted to men. In conclusion, the meta-analysis suggests that ALS risk is associated with use of pesticides as a group, and our analysis of AHS data points to OC use in particular. The latter results are novel but based on a small number of cases and require replication in other populations.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Agricultural Workers' Diseases - chemically induced</subject><subject>Agricultural Workers' Diseases - mortality</subject><subject>Agriculture</subject><subject>Aldrin</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - chemically induced</subject><subject>Amyotrophic Lateral Sclerosis - mortality</subject><subject>Biological and medical sciences</subject><subject>Cerebrospinal fluid. Meninges. Spinal cord</subject><subject>Cohort study</subject><subject>Data processing</subject><subject>DDT</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dieldrin</subject><subject>Female</subject><subject>Fumigants</subject><subject>Herbicides</subject><subject>Humans</subject><subject>Hydrocarbons, Chlorinated - adverse effects</subject><subject>Insecticides</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Motor neuron disease</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Occupational Exposure</subject><subject>Odds Ratio</subject><subject>Organochlorine compounds</subject><subject>Organochlorine insecticides</subject><subject>Pesticides</subject><subject>Pesticides - adverse effects</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Pyrethroids</subject><subject>Replication</subject><subject>Reviews</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Spouses</subject><subject>Statistical analysis</subject><subject>Toxaphene</subject><subject>Toxicology</subject><issn>0161-813X</issn><issn>1872-9711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSLbb_IJC8aXQix2NZK2sQwoh9AsC7SGF3IQ-xo0Wr7WR7ND8-yjZbdpcetJhnhm970PIW6ANUFidrpsR5xQbRoE1tG0ohQOygE6yWkmAV2RRKKg74NfH5HXO6wIIuVJH5JgxwYCBWpD2B-YpuOCxwt_bmOeElRl9ZTb3cUpxexNcNZgJkxmq7AZMMYf8hhz2Zsh4sn-X5OfnT1cXX-vL71--XZxf1k4wNtVeKkOF4rylnHnlVQ-9Qt9TZW1nHeu5lNZ5tA6FEdaItrOqFSvFPJcKLF-Sj7u729lu0Dscp5JDb1PYmHSvown65WQMN_pXvNOci64txZfkw_5Airdzaao3ITscBjNinLMGymjXctaxgvId6krFnLB__gaofvSt1_rJt370rWmri86y9e7fhM87fwQX4P0eMNmZoU9mdCH_5VYUQMqucGc7DovPu4BJZxdwdOhDQjdpH8N_gzwAdBihAQ</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Kamel, Freya</creator><creator>Umbach, David M.</creator><creator>Bedlack, Richard S.</creator><creator>Richards, Marie</creator><creator>Watson, Mary</creator><creator>Alavanja, Michael C.R.</creator><creator>Blair, Aaron</creator><creator>Hoppin, Jane A.</creator><creator>Schmidt, Silke</creator><creator>Sandler, Dale P.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TK</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20120601</creationdate><title>Pesticide exposure and amyotrophic lateral sclerosis</title><author>Kamel, Freya ; Umbach, David M. ; Bedlack, Richard S. ; Richards, Marie ; Watson, Mary ; Alavanja, Michael C.R. ; Blair, Aaron ; Hoppin, Jane A. ; Schmidt, Silke ; Sandler, Dale P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-d79a059334032d9d9f1f9edf09bb8bc2f377bcdebce5a5ba548b945692d3791b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Agricultural Workers' Diseases - chemically induced</topic><topic>Agricultural Workers' Diseases - mortality</topic><topic>Agriculture</topic><topic>Aldrin</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - chemically induced</topic><topic>Amyotrophic Lateral Sclerosis - mortality</topic><topic>Biological and medical sciences</topic><topic>Cerebrospinal fluid. Meninges. Spinal cord</topic><topic>Cohort study</topic><topic>Data processing</topic><topic>DDT</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dieldrin</topic><topic>Female</topic><topic>Fumigants</topic><topic>Herbicides</topic><topic>Humans</topic><topic>Hydrocarbons, Chlorinated - adverse effects</topic><topic>Insecticides</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Motor neuron disease</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Occupational Exposure</topic><topic>Odds Ratio</topic><topic>Organochlorine compounds</topic><topic>Organochlorine insecticides</topic><topic>Pesticides</topic><topic>Pesticides - adverse effects</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Pyrethroids</topic><topic>Replication</topic><topic>Reviews</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Spouses</topic><topic>Statistical analysis</topic><topic>Toxaphene</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamel, Freya</creatorcontrib><creatorcontrib>Umbach, David M.</creatorcontrib><creatorcontrib>Bedlack, Richard S.</creatorcontrib><creatorcontrib>Richards, Marie</creatorcontrib><creatorcontrib>Watson, Mary</creatorcontrib><creatorcontrib>Alavanja, Michael C.R.</creatorcontrib><creatorcontrib>Blair, Aaron</creatorcontrib><creatorcontrib>Hoppin, Jane A.</creatorcontrib><creatorcontrib>Schmidt, Silke</creatorcontrib><creatorcontrib>Sandler, Dale P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurotoxicology (Park Forest South)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamel, Freya</au><au>Umbach, David M.</au><au>Bedlack, Richard S.</au><au>Richards, Marie</au><au>Watson, Mary</au><au>Alavanja, Michael C.R.</au><au>Blair, Aaron</au><au>Hoppin, Jane A.</au><au>Schmidt, Silke</au><au>Sandler, Dale P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pesticide exposure and amyotrophic lateral sclerosis</atitle><jtitle>Neurotoxicology (Park Forest South)</jtitle><addtitle>Neurotoxicology</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>33</volume><issue>3</issue><spage>457</spage><epage>462</epage><pages>457-462</pages><issn>0161-813X</issn><eissn>1872-9711</eissn><abstract>► Pesticide exposure and amyotrophic lateral sclerosis. ► In a meta-analysis of 8 studies, ALS was associated with general pesticide exposure. ► In an agricultural cohort, ALS was associated with organochlorine insecticides. ► Specific pesticides associated with ALS were aldrin, dieldrin, DDT, and toxaphene.
Our objectives were to summarize literature on the association of amyotrophic lateral sclerosis (ALS) with pesticides as a group and to evaluate associations of ALS with specific pesticides. We conducted a meta-analysis of published studies of ALS and pesticides as a group and investigated the association of ALS with specific pesticides, using data from the Agricultural Health Study (AHS), a cohort including 84,739 private pesticide applicators and spouses. AHS participants provided information on pesticide use at enrollment in 1993–1997. In mortality data collected through February 2010, ALS was recorded on death certificates of 41 individuals whom we compared to the remaining cohort (controls), using unconditional logistic regression adjusted for age and gender to calculate odds ratios (ORs) and 95% confidence intervals. In the meta-analysis, ALS was associated with use of pesticides as a group (1.9, 1.1–3.1). In the AHS, ALS was not associated with pesticides as a group, but was associated with use of organochlorine insecticides (OCs) (1.6, 0.8–3.5), pyrethroids (1.4, 0.6–3.4), herbicides (1.6, 0.7–3.7), and fumigants (1.8, 0.8–3.9). ORs were elevated forever use of the specific OCs aldrin (2.1, 0.8–5.1), dieldrin (2.6, 0.9–7.3), DDT (2.1, 0.9–5.0), and toxaphene (2.0, 0.8–4.9). None of these associations was statistically significant. Similar results were observed in an analysis restricted to men. In conclusion, the meta-analysis suggests that ALS risk is associated with use of pesticides as a group, and our analysis of AHS data points to OC use in particular. The latter results are novel but based on a small number of cases and require replication in other populations.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>22521219</pmid><doi>10.1016/j.neuro.2012.04.001</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neurotoxicology (Park Forest South), 2012-06, Vol.33 (3), p.457-462 |
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| subjects | Age Factors Aged Agricultural Workers' Diseases - chemically induced Agricultural Workers' Diseases - mortality Agriculture Aldrin Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - chemically induced Amyotrophic Lateral Sclerosis - mortality Biological and medical sciences Cerebrospinal fluid. Meninges. Spinal cord Cohort study Data processing DDT Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dieldrin Female Fumigants Herbicides Humans Hydrocarbons, Chlorinated - adverse effects Insecticides Logistic Models Male Medical sciences Meta-analysis Middle Aged Mortality Motor neuron disease Nervous system (semeiology, syndromes) Neurology Occupational Exposure Odds Ratio Organochlorine compounds Organochlorine insecticides Pesticides Pesticides - adverse effects Pesticides, fertilizers and other agrochemicals toxicology Pyrethroids Replication Reviews Risk Assessment Risk Factors Sex Factors Spouses Statistical analysis Toxaphene Toxicology |
| title | Pesticide exposure and amyotrophic lateral sclerosis |
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