Quantitative proteomic analysis of HIV-1 infected CD4+ T cells reveals an early host response in important biological pathways: Protein synthesis, cell proliferation, and T-cell activation
Abstract Human immunodeficiency virus (HIV-1) depends upon host-encoded proteins to facilitate its replication while at the same time inhibiting critical components of innate and/or intrinsic immune response pathways. To characterize the host cell response on protein levels in CD4+ lymphoblastoid SU...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2012-07, Vol.429 (1), p.37-46 |
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| creator | Navare, Arti T Sova, Pavel Purdy, David E Weiss, Jeffrey M Wolf-Yadlin, Alejandro Korth, Marcus J Chang, Stewart T Proll, Sean C Jahan, Tahmina A Krasnoselsky, Alexei L Palermo, Robert E Katze, Michael G |
| description | Abstract Human immunodeficiency virus (HIV-1) depends upon host-encoded proteins to facilitate its replication while at the same time inhibiting critical components of innate and/or intrinsic immune response pathways. To characterize the host cell response on protein levels in CD4+ lymphoblastoid SUP-T1 cells after infection with HIV-1 strain LAI, we used mass spectrometry (MS)-based global quantitation with iTRAQ (isobaric tag for relative and absolute quantification). We found 266, 60 and 22 proteins differentially expressed (DE) ( P-value ≤0.05) at 4, 8, and 20 hours post-infection (hpi), respectively, compared to time-matched mock-infected samples. The majority of changes in protein abundance occurred at an early stage of infection well before the de novo production of viral proteins. Functional analyses of these DE proteins showed enrichment in several biological pathways including protein synthesis, cell proliferation, and T-cell activation. Importantly, these early changes before the time of robust viral production have not been described before. |
| doi_str_mv | 10.1016/j.virol.2012.03.026 |
| format | Article |
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To characterize the host cell response on protein levels in CD4+ lymphoblastoid SUP-T1 cells after infection with HIV-1 strain LAI, we used mass spectrometry (MS)-based global quantitation with iTRAQ (isobaric tag for relative and absolute quantification). We found 266, 60 and 22 proteins differentially expressed (DE) ( P-value ≤0.05) at 4, 8, and 20 hours post-infection (hpi), respectively, compared to time-matched mock-infected samples. The majority of changes in protein abundance occurred at an early stage of infection well before the de novo production of viral proteins. Functional analyses of these DE proteins showed enrichment in several biological pathways including protein synthesis, cell proliferation, and T-cell activation. Importantly, these early changes before the time of robust viral production have not been described before.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2012.03.026</identifier><identifier>PMID: 22542004</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; AIDS VIRUS ; BIOLOGICAL PATHWAYS ; BIOSYNTHESIS ; CD4 antigen ; CD4-Positive T-Lymphocytes - chemistry ; CD4-Positive T-Lymphocytes - cytology ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - virology ; Cell activation ; Cell Line ; CELL PROLIFERATION ; FUNCTIONAL ANALYSIS ; Gene Regulatory Networks ; HIV Infections - genetics ; HIV Infections - immunology ; HIV Infections - physiopathology ; HIV Infections - virology ; HIV-1 ; HIV-1 - genetics ; HIV-1 - physiology ; Host-Pathogen Interactions ; Human immunodeficiency virus 1 ; Humans ; Infection ; Infectious Disease ; iTRAQ ; LC-MS/MS ; Lymphocytes T ; MASS SPECTROSCOPY ; Protein Biosynthesis ; Protein quantification ; PROTEINS ; Proteomics ; Quantitation ; Replication ; Ribosomal proteins ; SPECIES DIVERSITY ; T-cells ; T-Lymphocytes - chemistry ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; T-Lymphocytes - virology</subject><ispartof>Virology (New York, N.Y.), 2012-07, Vol.429 (1), p.37-46</ispartof><rights>2012</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-48678a4d6e21d7aecda95a7db09d1fdec3adae1f944c655c7d7c880668516bcb3</citedby><cites>FETCH-LOGICAL-c575t-48678a4d6e21d7aecda95a7db09d1fdec3adae1f944c655c7d7c880668516bcb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.virol.2012.03.026$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22542004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22149282$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Navare, Arti T</creatorcontrib><creatorcontrib>Sova, Pavel</creatorcontrib><creatorcontrib>Purdy, David E</creatorcontrib><creatorcontrib>Weiss, Jeffrey M</creatorcontrib><creatorcontrib>Wolf-Yadlin, Alejandro</creatorcontrib><creatorcontrib>Korth, Marcus J</creatorcontrib><creatorcontrib>Chang, Stewart T</creatorcontrib><creatorcontrib>Proll, Sean C</creatorcontrib><creatorcontrib>Jahan, Tahmina A</creatorcontrib><creatorcontrib>Krasnoselsky, Alexei L</creatorcontrib><creatorcontrib>Palermo, Robert E</creatorcontrib><creatorcontrib>Katze, Michael G</creatorcontrib><title>Quantitative proteomic analysis of HIV-1 infected CD4+ T cells reveals an early host response in important biological pathways: Protein synthesis, cell proliferation, and T-cell activation</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>Abstract Human immunodeficiency virus (HIV-1) depends upon host-encoded proteins to facilitate its replication while at the same time inhibiting critical components of innate and/or intrinsic immune response pathways. To characterize the host cell response on protein levels in CD4+ lymphoblastoid SUP-T1 cells after infection with HIV-1 strain LAI, we used mass spectrometry (MS)-based global quantitation with iTRAQ (isobaric tag for relative and absolute quantification). We found 266, 60 and 22 proteins differentially expressed (DE) ( P-value ≤0.05) at 4, 8, and 20 hours post-infection (hpi), respectively, compared to time-matched mock-infected samples. The majority of changes in protein abundance occurred at an early stage of infection well before the de novo production of viral proteins. Functional analyses of these DE proteins showed enrichment in several biological pathways including protein synthesis, cell proliferation, and T-cell activation. Importantly, these early changes before the time of robust viral production have not been described before.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>AIDS VIRUS</subject><subject>BIOLOGICAL PATHWAYS</subject><subject>BIOSYNTHESIS</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - chemistry</subject><subject>CD4-Positive T-Lymphocytes - cytology</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - virology</subject><subject>Cell activation</subject><subject>Cell Line</subject><subject>CELL PROLIFERATION</subject><subject>FUNCTIONAL ANALYSIS</subject><subject>Gene Regulatory Networks</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - physiopathology</subject><subject>HIV Infections - virology</subject><subject>HIV-1</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - physiology</subject><subject>Host-Pathogen Interactions</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Infection</subject><subject>Infectious Disease</subject><subject>iTRAQ</subject><subject>LC-MS/MS</subject><subject>Lymphocytes T</subject><subject>MASS SPECTROSCOPY</subject><subject>Protein Biosynthesis</subject><subject>Protein quantification</subject><subject>PROTEINS</subject><subject>Proteomics</subject><subject>Quantitation</subject><subject>Replication</subject><subject>Ribosomal proteins</subject><subject>SPECIES DIVERSITY</subject><subject>T-cells</subject><subject>T-Lymphocytes - chemistry</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>T-Lymphocytes - virology</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUl1vEzEQPCEQLYVfgIQs8YJEL9g-n-9SiUoofLRSJUAEXi3H3mscLvZhO0H5b_w49pJSAS99Wtme2dlZT1E8ZXTCKJOvVpOti6GfcMr4hFYTyuW94pjRqSxpJdj94phSwUvZcn5UPEppRfHcNPRhccR5LTiejotfnzfaZ5d1dlsgQwwZwtoZor3ud8klEjpycfmtZMT5DkwGS2ZvxUsyJwb6PpEIW9BYtSegY78jy5Ay3qYh-ARIIm49hJhRhCxc6MO1M7ong87Ln3qXzsinURJhaefzElDxdN95HKV3HUQcLPhT7G_JvNy_aIOz7q8fFw86FIcnN_Wk-Pr-3Xx2UV59_HA5e3NVmrqpcyla2bRaWAmc2UaDsXpa68Yu6NSyzoKptNXAuqkQRta1aWxj2pZK2dZMLsyiOinOD32HzWIN1oDPUfdqiG6t404F7dS_L94t1XXYqqqqW0EbbPD80ACX41QyLoNZmuA9blRxzsSUtxxRL25kYvixgZTV2qXRsvYQNkkx_NaWUYn1biiruZBiOmpXB6iJIaUI3e3cjI44qVZqHyQ1BknRSmGQkPXsb8u3nD_JQcDrAwBw8VsHcbQF3oB1cXRlg7tD4Pw_vumdH8PxHXaQVmETMYLoRCXkqC9jlscoM1Rnrair31g99BE</recordid><startdate>20120720</startdate><enddate>20120720</enddate><creator>Navare, Arti T</creator><creator>Sova, Pavel</creator><creator>Purdy, David E</creator><creator>Weiss, Jeffrey M</creator><creator>Wolf-Yadlin, Alejandro</creator><creator>Korth, Marcus J</creator><creator>Chang, Stewart T</creator><creator>Proll, Sean C</creator><creator>Jahan, Tahmina A</creator><creator>Krasnoselsky, Alexei L</creator><creator>Palermo, Robert E</creator><creator>Katze, Michael G</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20120720</creationdate><title>Quantitative proteomic analysis of HIV-1 infected CD4+ T cells reveals an early host response in important biological pathways: Protein synthesis, cell proliferation, and T-cell activation</title><author>Navare, Arti T ; Sova, Pavel ; Purdy, David E ; Weiss, Jeffrey M ; Wolf-Yadlin, Alejandro ; Korth, Marcus J ; Chang, Stewart T ; Proll, Sean C ; Jahan, Tahmina A ; Krasnoselsky, Alexei L ; Palermo, Robert E ; Katze, Michael G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-48678a4d6e21d7aecda95a7db09d1fdec3adae1f944c655c7d7c880668516bcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>AIDS VIRUS</topic><topic>BIOLOGICAL PATHWAYS</topic><topic>BIOSYNTHESIS</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - chemistry</topic><topic>CD4-Positive T-Lymphocytes - cytology</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - virology</topic><topic>Cell activation</topic><topic>Cell Line</topic><topic>CELL PROLIFERATION</topic><topic>FUNCTIONAL ANALYSIS</topic><topic>Gene Regulatory Networks</topic><topic>HIV Infections - genetics</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - physiopathology</topic><topic>HIV Infections - virology</topic><topic>HIV-1</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - physiology</topic><topic>Host-Pathogen Interactions</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Infection</topic><topic>Infectious Disease</topic><topic>iTRAQ</topic><topic>LC-MS/MS</topic><topic>Lymphocytes T</topic><topic>MASS SPECTROSCOPY</topic><topic>Protein Biosynthesis</topic><topic>Protein quantification</topic><topic>PROTEINS</topic><topic>Proteomics</topic><topic>Quantitation</topic><topic>Replication</topic><topic>Ribosomal proteins</topic><topic>SPECIES DIVERSITY</topic><topic>T-cells</topic><topic>T-Lymphocytes - chemistry</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>T-Lymphocytes - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Navare, Arti T</creatorcontrib><creatorcontrib>Sova, Pavel</creatorcontrib><creatorcontrib>Purdy, David E</creatorcontrib><creatorcontrib>Weiss, Jeffrey M</creatorcontrib><creatorcontrib>Wolf-Yadlin, Alejandro</creatorcontrib><creatorcontrib>Korth, Marcus J</creatorcontrib><creatorcontrib>Chang, Stewart T</creatorcontrib><creatorcontrib>Proll, Sean C</creatorcontrib><creatorcontrib>Jahan, Tahmina A</creatorcontrib><creatorcontrib>Krasnoselsky, Alexei L</creatorcontrib><creatorcontrib>Palermo, Robert E</creatorcontrib><creatorcontrib>Katze, Michael G</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Navare, Arti T</au><au>Sova, Pavel</au><au>Purdy, David E</au><au>Weiss, Jeffrey M</au><au>Wolf-Yadlin, Alejandro</au><au>Korth, Marcus J</au><au>Chang, Stewart T</au><au>Proll, Sean C</au><au>Jahan, Tahmina A</au><au>Krasnoselsky, Alexei L</au><au>Palermo, Robert E</au><au>Katze, Michael G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative proteomic analysis of HIV-1 infected CD4+ T cells reveals an early host response in important biological pathways: Protein synthesis, cell proliferation, and T-cell activation</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>2012-07-20</date><risdate>2012</risdate><volume>429</volume><issue>1</issue><spage>37</spage><epage>46</epage><pages>37-46</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><abstract>Abstract Human immunodeficiency virus (HIV-1) depends upon host-encoded proteins to facilitate its replication while at the same time inhibiting critical components of innate and/or intrinsic immune response pathways. To characterize the host cell response on protein levels in CD4+ lymphoblastoid SUP-T1 cells after infection with HIV-1 strain LAI, we used mass spectrometry (MS)-based global quantitation with iTRAQ (isobaric tag for relative and absolute quantification). We found 266, 60 and 22 proteins differentially expressed (DE) ( P-value ≤0.05) at 4, 8, and 20 hours post-infection (hpi), respectively, compared to time-matched mock-infected samples. The majority of changes in protein abundance occurred at an early stage of infection well before the de novo production of viral proteins. Functional analyses of these DE proteins showed enrichment in several biological pathways including protein synthesis, cell proliferation, and T-cell activation. Importantly, these early changes before the time of robust viral production have not been described before.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22542004</pmid><doi>10.1016/j.virol.2012.03.026</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 60 APPLIED LIFE SCIENCES AIDS VIRUS BIOLOGICAL PATHWAYS BIOSYNTHESIS CD4 antigen CD4-Positive T-Lymphocytes - chemistry CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Cell activation Cell Line CELL PROLIFERATION FUNCTIONAL ANALYSIS Gene Regulatory Networks HIV Infections - genetics HIV Infections - immunology HIV Infections - physiopathology HIV Infections - virology HIV-1 HIV-1 - genetics HIV-1 - physiology Host-Pathogen Interactions Human immunodeficiency virus 1 Humans Infection Infectious Disease iTRAQ LC-MS/MS Lymphocytes T MASS SPECTROSCOPY Protein Biosynthesis Protein quantification PROTEINS Proteomics Quantitation Replication Ribosomal proteins SPECIES DIVERSITY T-cells T-Lymphocytes - chemistry T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - virology |
| title | Quantitative proteomic analysis of HIV-1 infected CD4+ T cells reveals an early host response in important biological pathways: Protein synthesis, cell proliferation, and T-cell activation |
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