Reducing expression of GluN10XX subunit splice variants of the NMDA receptor interferes with spatial reference memory

► Injection of GluN10XX specific siRNA into mice brain showed localized reduction of its mRNA expression. ► Mice with reduced GluN10XX expression showed impairment in reference memory testing. ► GluN10XX splice variants might be involved with memory acquisition and/or consolidation. The GluN1 subuni...

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Veröffentlicht in:	Behavioural brain research 2012-05, Vol.230 (2), p.317-324
Hauptverfasser:	Das, Siba R., Jensen, Ross, Kelsay, Rian, Shumaker, Michelle, Bochart, Rachele, Brim, Brenna, Zamzow, Daniel, Magnusson, Kathy R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Memory NMDA receptor NR1 siRNA Splice variant Zeta1
Online-Zugang:	Volltext
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