Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction

Abstract Aberrant DNA methylation patterns have been linked to molecular and cellular alterations in the aging brain. Caloric restriction (CR) and upregulation of antioxidants have been proposed as interventions to prevent or delay age-related brain pathology. Previously, we have shown in large coho...

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Veröffentlicht in:	Neurobiology of aging 2012-08, Vol.33 (8), p.1672-1681
Hauptverfasser:	Chouliaras, Leonidas, van den Hove, Daniel L.A, Kenis, Gunter, Keitel, Stella, Hof, Patrick R, van Os, Jim, Steinbusch, Harry W.M, Schmitz, Christoph, Rutten, Bart P.F
Format:	Artikel
Sprache:	eng
Schlagworte:	5-methylcytidine (5-mC) Age Aging Aging - metabolism Animals Antioxidants Brain Caloric restriction Caloric Restriction - methods Cytidine - analogs & derivatives Cytidine - metabolism Dentate gyrus Dietary restrictions Diets DNA Methylation DNA methyltransferase DNA Methyltransferase 3A Epigenesis Epigenetics Hippocampus Hippocampus - metabolism Immunoreactivity Internal Medicine Male Mice Mice, Inbred C57BL Mice, Transgenic Nervous system Neurology Superoxide dismutase Superoxide dismutase (SOD) Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1
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