In Vitro and in Vivo mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

Biodegradable core−shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a view toward delivery of mRNA-based vaccines. The pH-responsive PBAE component was chosen to promote endosome disruption,...

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Veröffentlicht in:	Molecular pharmaceutics 2011-06, Vol.8 (3), p.774-787
Hauptverfasser:	Su, Xingfang, Fricke, Jennifer, Kavanagh, Daniel G, Irvine, Darrell J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Drug Carriers - chemistry Hydrogen-Ion Concentration Lipids - chemistry Mice Mice, Inbred BALB C Nanoparticles - administration & dosage Nanoparticles - chemistry Polymers - chemistry RNA, Messenger - administration & dosage RNA, Messenger - chemistry
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