TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis

Transmembrane BAX inhibitor motif-containing (TMBIM)-6, also known as BAX-inhibitor 1 (BI-1), is an anti-apoptotic protein that belongs to a putative family of highly conserved and poorly characterized genes. Here we report the function of TMBIM3/GRINA in the control of cell death by endoplasmic ret...

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Veröffentlicht in:	Cell death and differentiation 2012-06, Vol.19 (6), p.1013-1026
Hauptverfasser:	Rojas-Rivera, D, Armisén, R, Colombo, A, Martínez, G, Eguiguren, A L, Díaz, A, Kiviluoto, S, Rodríguez, D, Patron, M, Rizzuto, R, Bultynck, G, Concha, M L, Sierralta, J, Stutzin, A, Hetz, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319/1557 631/80/82/23 631/80/86/1999 Activating Transcription Factor 4 - metabolism Animal models Animals Apoptosis Bax protein Bcl-2 protein Biochemistry Biomedical and Life Sciences Calcium - metabolism Calcium homeostasis Cell Biology Cell Cycle Analysis Cell death Danio rerio Drosophila melanogaster eIF-2 Kinase - metabolism Embryos Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress Fibroblasts - metabolism Genes Genetic engineering HEK293 Cells HeLa Cells Homeostasis Humans Inositol 1,4,5-trisphosphate receptors Inositol 1,4,5-Trisphosphate Receptors - metabolism Life Sciences Medicine Membrane Proteins - antagonists & inhibitors Membrane Proteins - genetics Membrane Proteins - metabolism Mice mRNA Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurosciences Original Paper Protein folding Proteins Public health RNA Interference RNA, Small Interfering - metabolism Signal Transduction Stem Cells Stress Transcription factors Unfolded Protein Response - genetics Zebrafish
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