An epistatic mini-circuitry between the transcription factors Snail and HNF4α controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs

Preservation of the epithelial state involves the stable repression of epithelial-to-mesenchymal transition program, whereas maintenance of the stem compartment requires the inhibition of differentiation processes. A simple and direct molecular mini-circuitry between master elements of these biologi...

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Veröffentlicht in:	Cell death and differentiation 2012-06, Vol.19 (6), p.937-946
Hauptverfasser:	Garibaldi, F, Cicchini, C, Conigliaro, A, Santangelo, L, Cozzolino, A M, Grassi, G, Marchetti, A, Tripodi, M, Amicone, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biochemistry Biochemistry, Molecular Biology Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell Differentiation Cellular Biology Epithelial-Mesenchymal Transition Hepatocyte Nuclear Factor 4 Hepatocyte Nuclear Factor 4 - deficiency Hepatocyte Nuclear Factor 4 - genetics Hepatocyte Nuclear Factor 4 - metabolism Hepatocytes Hepatocytes - metabolism Life Sciences Liver Liver - cytology Liver - metabolism Mice Mice, Knockout MicroRNAs MicroRNAs - metabolism Original Paper Snail Family Transcription Factors Stem Cells Stem Cells - metabolism Transcription Factors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
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