HJURP Uses Distinct CENP-A Surfaces to Recognize and to Stabilize CENP-A/Histone H4 for Centromere Assembly

Centromeres are defined by the presence of chromatin containing the histone H3 variant, CENP-A, whose assembly into nucleosomes requires the chromatin assembly factor HJURP. We find that whereas surface-exposed residues in the CENP-A targeting domain (CATD) are the primary sequence determinants for...

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Veröffentlicht in:	Developmental cell 2012-04, Vol.22 (4), p.749-762
Hauptverfasser:	Bassett, Emily A., DeNizio, Jamie, Barnhart-Dailey, Meghan C., Panchenko, Tanya, Sekulic, Nikolina, Rogers, Danielle J., Foltz, Daniel R., Black, Ben E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Autoantigens - chemistry Autoantigens - metabolism Binding Sites Biological and medical sciences Cell Cycle Cell differentiation, maturation, development, hematopoiesis Cell physiology Centromere - physiology Centromere Protein A Centromeres Chaperones Chromatin Chromatin Assembly and Disassembly Chromatin remodeling Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - metabolism Data processing DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology HeLa Cells Histone H3 Histone H4 Histones - chemistry Histones - metabolism Humans Immunoblotting Mass Spectrometry Molecular and cellular biology Molecular Sequence Data Nucleosomes Nucleosomes - physiology Protein Binding Protein Conformation Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid
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