Acute administration of typical and atypical antipsychotics reduces EEG gamma power, but only the preclinical compound LY379268 reduces the ketamine-induced rise in gamma power

A single non-anaesthetic dose of ketamine, a non-competitive NMDA receptor (NMDAR) antagonist with hallucinogenic properties, induces cognitive impairment and psychosis, and aggravates schizophrenia symptoms in patients. In conscious rats an equivalent dose of ketamine induces key features of animal...

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Veröffentlicht in:	The international journal of neuropsychopharmacology 2012-06, Vol.15 (5), p.657-668
Hauptverfasser:	Jones, Nigel C., Reddy, Maya, Anderson, Paul, Salzberg, Michael R., O'Brien, Terence J., Pinault, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids Amino Acids - administration & dosage Amino Acids - pharmacology Animal models Animals Antipsychotic Agents Antipsychotic Agents - administration & dosage Antipsychotic Agents - pharmacology Antipsychotics Auditory evoked potentials Bicyclo Compounds, Heterocyclic Brain Waves Brain Waves - drug effects Bridged Bicyclo Compounds, Heterocyclic - administration & dosage Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cerebral Cortex Cerebral Cortex - drug effects Channel gating Clozapine Clozapine - administration & dosage Clozapine - pharmacokinetics Cognitive ability Cortex Drug Administration Schedule Drugs EEG Electrodes Electrodes, Implanted Excitatory Amino Acid Antagonists Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - pharmacology Glutamic acid receptors Glutamic acid receptors (ionotropic) Haloperidol Haloperidol - administration & dosage Haloperidol - pharmacology Ketamine Ketamine - administration & dosage Ketamine - pharmacology Life Sciences Locomotor activity Male N-Methyl-D-aspartic acid receptors Neuroleptics Neurons and Cognition Oscillations Psychosis Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Schizophrenia Skull
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