Chronic exposure to methylphenidate impairs appendicular bone quality in young rats

Abstract Methylphenidate (MP) is a psychostimulant widely prescribed to treat Attention Deficit Hyperactivity Disorder (ADHD). Although generally well tolerated, growth deficits have been reported in children and adolescents undergoing MP treatment. This study was designed to elucidate the skeletal...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2012-06, Vol.50 (6), p.1214-1222
Hauptverfasser:	Komatsu, David E, Thanos, Panayotis K, Mary, Michelle N, Janda, Haden A, John, Christine M, Robison, Lisa, Ananth, Mala, Swanson, James M, Volkow, Nora D, Hadjiargyrou, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Adolescent Alkaline Phosphatase - blood Animals Attention deficit hyperactivity disorder Biological and medical sciences Biomarkers - blood Biomechanical Phenomena Biomechanics Biomechanics. Biorheology Bone (appendicular) Bone (long) Bone and Bones - drug effects Bone and Bones - pathology Bone and Bones - physiopathology Bone Density - drug effects Bone Development - drug effects Bone mineral content Bone mineral density Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - toxicity Children Chronic exposure Collagen Type I - blood Dose-Response Relationship, Drug Drinking water Dual energy X-ray absorptiometry DXA Energy Femur Fractures Fundamental and applied biological sciences. Psychology Growth suppression Humans Male Mechanical properties Methylphenidate Methylphenidate - administration & dosage Methylphenidate - toxicity Models, Animal Orthopedics Peptides - blood Rats Rats, Sprague-Dawley Risk Factors Skeleton Spine Statistical analysis Testosterone Testosterone - blood Time Factors Tissues, organs and organisms biophysics Vertebrae Vertebrates: anatomy and physiology, studies on body, several organs or systems
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