Envelope and pre-membrane protein structural amino acid mutations mediate diminished avian growth and virulence of a Mexican West Nile virus isolate

The hallmark attribute of North American West Nile virus (WNV) strains has been high pathogenicity in certain bird species. Surprisingly, this avian virulent WNV phenotype has not been observed during its geographical expansion into the Caribbean, Central America and South America. One WNV variant (...

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Veröffentlicht in:	Journal of general virology 2011-12, Vol.92 (Pt 12), p.2810-2820
Hauptverfasser:	Langevin, Stanley A, Bowen, Richard A, Ramey, Wanichaya N, Sanders, Todd A, Maharaj, Payal D, Fang, Ying, Cornelius, Jennine, Barker, Christopher M, Reisen, William K, Beasley, David W. C, Barrett, Alan D. T, Kinney, Richard M, Huang, Claire Y.-H, Brault, Aaron C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution amino acids Animal Animals Biological and medical sciences Bird Diseases - virology cell culture Cell Line Chickens chimerism Cloning, Molecular crows Crows - virology DNA, Complementary - genetics Finches - virology Fundamental and applied biological sciences. Psychology genes hosts macrophages Membrane Proteins - genetics Mexico Microbiology Miscellaneous Mutation Passer domesticus Phenotype Phylogeography Plasmids - genetics Sequence Analysis, DNA Sparrows - virology structural proteins Viral Envelope Proteins - genetics Viral Envelope Proteins - metabolism Viral Load Virology Virulence Virus Replication viruses West Nile virus West Nile virus - genetics West Nile virus - isolation & purification West Nile virus - pathogenicity
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