Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells

Generation of induced pluripotent stem cells （iPSCs） has opened new avenues for the investigation of heart diseases, drug screening and potential autologous cardiac regeneration. However, their application is hampered by inefficient cardiac differentiation, high interline variability, and poor matur...

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Veröffentlicht in:	Cell research 2012-01, Vol.22 (1), p.219-236
Hauptverfasser:	Cao, Nan, Liu, Zumei, Chen, Zhongyan, Wang, Jia, Chen, Taotao, Zhao, Xiaoyang, Ma, Yu, Qin, Lianju, Kang, Jiuhong, Wei, Bin, Wang, Liu, Jin, Ying, Yang, Huang-Tian
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/532/2064/2158 631/443/592/2725 631/45/72/1206 631/61/490 Acetylcholine receptors (muscarinic) Action potential Animals Apoptosis Ascorbic acid Ascorbic Acid - pharmacology Autografts Biomarkers - metabolism Biomedical and Life Sciences Calcium cardiomyocytes Cardiovascular diseases Cell Biology Cell Differentiation Cell Proliferation Collagen Collagen - biosynthesis Culture Media - metabolism Differentiation Drug screening Flow Cytometry Heart Heart diseases Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Inhibitory postsynaptic potentials Life Sciences MAP Kinase Signaling System Mesoderm - cytology Mesoderm - drug effects Mesoderm - metabolism Mice Microenvironments Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Original original-article Patch-Clamp Techniques Plasmids - genetics Plasmids - metabolism Stem cells Time Factors Transfection 增殖多能干细胞心肌分化心肌细胞心脏疾病抗坏血酸祖细胞诱导
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