Structural Factors and Mechanisms Underlying the Improved Photodynamic Cell Killing with Silicon Phthalocyanine Photosensitizers Directed to Lysosomes Versus Mitochondria

The phthalocyanine photosensitizer Pc 4 has been shown to bind preferentially to mitochondrial and endoplasmic reticulum membranes. Upon photoirradiation of Pc 4‐loaded cells, membrane components, especially Bcl‐2, are photodamaged and apoptosis, as indicated by activation of caspase‐3 and cleavage...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Photochemistry and photobiology 2009-09, Vol.85 (5), p.1189-1200
Hauptverfasser:	Rodriguez, Myriam E., Zhang, Ping, Azizuddin, Kashif, Delos Santos, Grace B., Chiu, Song-mao, Xue, Liang-yan, Berlin, Jeffery C., Peng, Xinzhan, Wu, Hongqiao, Lam, Minh, Nieminen, Anna-Liisa, Kenney, Malcolm E., Oleinick, Nancy L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer Cells Evaporation Indoles - pharmacology Lysosomes - drug effects Magnetic Resonance Spectroscopy Mitochondria Mitochondria - drug effects Photochemotherapy Photodynamic therapy Photosensitizing Agents - pharmacology Silicon Silicon - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!