Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia
Purpose To analyze the clinical pattern of ocular toxoplasmosis (OT) in a referral centre in Serbia. Patients and methods The medical records of consecutive patients admitted for OT to the single referral centre for uveitis in Serbia between 2006 and 2010 were retrospectively analyzed. OT was diagno...
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| Veröffentlicht in: | Eye (London) 2012-05, Vol.26 (5), p.723-728 |
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| creator | KOVACEVIC-PAVICEVIC, D RADOSAVLJEVIC, A ILIC, A KOVACEVIC, I DJURKOVIC-DJAKOVIC, O |
| description | Purpose
To analyze the clinical pattern of ocular toxoplasmosis (OT) in a referral centre in Serbia.
Patients and methods
The medical records of consecutive patients admitted for OT to the single referral centre for uveitis in Serbia between 2006 and 2010 were retrospectively analyzed. OT was diagnosed on the basis of typical fundus lesions and positive serology for Toxoplasma.
Results
In a total of 457 uveitis patients, OT was the third leading cause, with 59 patients (12.9%). Most OT cases (73%) were monocular. An active primary retinal lesion was observed in 36% and recurrent OT in 64% patients. Localization of lesions was central/paracentral (44%), juxtapapillar (27%), peripheral (19%), and multifocal (10%). Other ocular manifestations of inflammation included vitritis (44%), anterior uveitis (19%), and retinal vasculitis (10%). Complications included choroidal neovascularization in two and exudative retinal detachment with cataract, glaucoma, and cystoid macular oedema in one patient each. The detection of Toxoplasma-specific IgM antibodies in a single patient indicates a low rate of OT concomitant with acute infection. After treatment, the mean best-corrected visual acuity (BCVA) increased significantly. However, 14 (24%) patients ended up legally blind in the affected eye, of which 2 (3%) with bilateral blindness, all with a very poor BCVA (0.047±0.055) at presentation. Visual impairment and treatment outcome were both associated with central localization of lesions (
P |
| doi_str_mv | 10.1038/eye.2012.20 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3351055</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1012745974</sourcerecordid><originalsourceid>FETCH-LOGICAL-c509t-843a22e3388d91da38c052a18b2351852eff85bc721d4cb02882842c74310cd93</originalsourceid><addsrcrecordid>eNqNkc2LFDEQxYMo7jh68i4NIgjaa1JJptMXQQa_YGEPKngL1enqNUtPMibd4v73pp1xXfXipQJ5v1S91GPsoeCngkvzgq7oFLiAUm6xlVDNptZKq9tsxVvNawD4fMLu5XzJeREbfpedAMiNMKpZsfPt6IN3OFZ7nCZKoYpDFd08Yqqm-D3uR8y7mH2upkQ4UV_5UGGVaKCUyitHoQjL5QdKncf77M6AY6YHx3PNPr15_XH7rj47f_t---qsdpq3U22URACS0pi-FT1K47gGFKYDqYXRQMNgdOcaEL1yHQdjwChwjZKCu76Va_by0Hc_dzvqf9rA0e6T32G6shG9_VMJ_ou9iN-sLP251qXB02ODFL_OlCe789nROGKgOGcrykwOUijzH6iARum2mFuzx3-hl3FOoWxioUQrteSbQj07UC7FnMsur30LbpdMbcnULpmWUuhHN796zf4KsQBPjgDmkuSQMDiff3PaGMX1srPnBy4XKVxQumnu37k_AJxvtyY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1011935306</pqid></control><display><type>article</type><title>Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>KOVACEVIC-PAVICEVIC, D ; RADOSAVLJEVIC, A ; ILIC, A ; KOVACEVIC, I ; DJURKOVIC-DJAKOVIC, O</creator><creatorcontrib>KOVACEVIC-PAVICEVIC, D ; RADOSAVLJEVIC, A ; ILIC, A ; KOVACEVIC, I ; DJURKOVIC-DJAKOVIC, O</creatorcontrib><description>Purpose
To analyze the clinical pattern of ocular toxoplasmosis (OT) in a referral centre in Serbia.
Patients and methods
The medical records of consecutive patients admitted for OT to the single referral centre for uveitis in Serbia between 2006 and 2010 were retrospectively analyzed. OT was diagnosed on the basis of typical fundus lesions and positive serology for Toxoplasma.
Results
In a total of 457 uveitis patients, OT was the third leading cause, with 59 patients (12.9%). Most OT cases (73%) were monocular. An active primary retinal lesion was observed in 36% and recurrent OT in 64% patients. Localization of lesions was central/paracentral (44%), juxtapapillar (27%), peripheral (19%), and multifocal (10%). Other ocular manifestations of inflammation included vitritis (44%), anterior uveitis (19%), and retinal vasculitis (10%). Complications included choroidal neovascularization in two and exudative retinal detachment with cataract, glaucoma, and cystoid macular oedema in one patient each. The detection of Toxoplasma-specific IgM antibodies in a single patient indicates a low rate of OT concomitant with acute infection. After treatment, the mean best-corrected visual acuity (BCVA) increased significantly. However, 14 (24%) patients ended up legally blind in the affected eye, of which 2 (3%) with bilateral blindness, all with a very poor BCVA (0.047±0.055) at presentation. Visual impairment and treatment outcome were both associated with central localization of lesions (
P
<0.0001 and
P
=0.006, respectively).
Conclusion
OT is a significant cause of posterior uveitis in Serbia. Patients should be aware of the recurring nature of OT and react immediately if symptoms occur.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.2012.20</identifier><identifier>PMID: 22361847</identifier><identifier>CODEN: EYEEEC</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699 ; 692/699/255/1715 ; 692/700/478/174 ; Acuity ; Adult ; Antibodies, Protozoan - blood ; Antiprotozoal Agents - therapeutic use ; Biological and medical sciences ; Blindness ; Cataracts ; Choroidal Neovascularization - epidemiology ; Choroidal Neovascularization - immunology ; Choroidal Neovascularization - parasitology ; Clinical Study ; Edema ; Enzyme-Linked Immunosorbent Assay ; Eye ; Female ; Fluorescein Angiography ; Glaucoma ; Glaucoma - epidemiology ; Glaucoma - immunology ; Glaucoma - parasitology ; Human protozoal diseases ; Humans ; Immunoglobulin G - blood ; Immunoglobulin M ; Immunoglobulin M - blood ; Infectious diseases ; Inflammation ; Laboratory Medicine ; Male ; medical records ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Miscellaneous ; Ophthalmology ; Parasitic diseases ; Pharmaceutical Sciences/Technology ; Protozoal diseases ; Referral and Consultation ; Retina ; Retinal Detachment - epidemiology ; Retinal Detachment - immunology ; Retinal Detachment - parasitology ; Retrospective Studies ; Serbia - epidemiology ; Serology ; Surgery ; Surgical Oncology ; Tomography, Optical Coherence ; Toxoplasma - immunology ; Toxoplasmosis ; Toxoplasmosis, Ocular - epidemiology ; Toxoplasmosis, Ocular - immunology ; Toxoplasmosis, Ocular - parasitology ; Uvea diseases ; Uveitis ; Uveitis - epidemiology ; Uveitis - immunology ; Uveitis - parasitology ; vascularization ; Vasculitis ; Visual Acuity - physiology</subject><ispartof>Eye (London), 2012-05, Vol.26 (5), p.723-728</ispartof><rights>Royal College of Ophthalmologists 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2012</rights><rights>Copyright © 2012 Royal College of Ophthalmologists 2012 Royal College of Ophthalmologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-843a22e3388d91da38c052a18b2351852eff85bc721d4cb02882842c74310cd93</citedby><cites>FETCH-LOGICAL-c509t-843a22e3388d91da38c052a18b2351852eff85bc721d4cb02882842c74310cd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351055/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351055/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25884059$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22361847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOVACEVIC-PAVICEVIC, D</creatorcontrib><creatorcontrib>RADOSAVLJEVIC, A</creatorcontrib><creatorcontrib>ILIC, A</creatorcontrib><creatorcontrib>KOVACEVIC, I</creatorcontrib><creatorcontrib>DJURKOVIC-DJAKOVIC, O</creatorcontrib><title>Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Purpose
To analyze the clinical pattern of ocular toxoplasmosis (OT) in a referral centre in Serbia.
Patients and methods
The medical records of consecutive patients admitted for OT to the single referral centre for uveitis in Serbia between 2006 and 2010 were retrospectively analyzed. OT was diagnosed on the basis of typical fundus lesions and positive serology for Toxoplasma.
Results
In a total of 457 uveitis patients, OT was the third leading cause, with 59 patients (12.9%). Most OT cases (73%) were monocular. An active primary retinal lesion was observed in 36% and recurrent OT in 64% patients. Localization of lesions was central/paracentral (44%), juxtapapillar (27%), peripheral (19%), and multifocal (10%). Other ocular manifestations of inflammation included vitritis (44%), anterior uveitis (19%), and retinal vasculitis (10%). Complications included choroidal neovascularization in two and exudative retinal detachment with cataract, glaucoma, and cystoid macular oedema in one patient each. The detection of Toxoplasma-specific IgM antibodies in a single patient indicates a low rate of OT concomitant with acute infection. After treatment, the mean best-corrected visual acuity (BCVA) increased significantly. However, 14 (24%) patients ended up legally blind in the affected eye, of which 2 (3%) with bilateral blindness, all with a very poor BCVA (0.047±0.055) at presentation. Visual impairment and treatment outcome were both associated with central localization of lesions (
P
<0.0001 and
P
=0.006, respectively).
Conclusion
OT is a significant cause of posterior uveitis in Serbia. Patients should be aware of the recurring nature of OT and react immediately if symptoms occur.</description><subject>692/699</subject><subject>692/699/255/1715</subject><subject>692/700/478/174</subject><subject>Acuity</subject><subject>Adult</subject><subject>Antibodies, Protozoan - blood</subject><subject>Antiprotozoal Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blindness</subject><subject>Cataracts</subject><subject>Choroidal Neovascularization - epidemiology</subject><subject>Choroidal Neovascularization - immunology</subject><subject>Choroidal Neovascularization - parasitology</subject><subject>Clinical Study</subject><subject>Edema</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Eye</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Glaucoma</subject><subject>Glaucoma - epidemiology</subject><subject>Glaucoma - immunology</subject><subject>Glaucoma - parasitology</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulin M - blood</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>medical records</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Parasitic diseases</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Protozoal diseases</subject><subject>Referral and Consultation</subject><subject>Retina</subject><subject>Retinal Detachment - epidemiology</subject><subject>Retinal Detachment - immunology</subject><subject>Retinal Detachment - parasitology</subject><subject>Retrospective Studies</subject><subject>Serbia - epidemiology</subject><subject>Serology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tomography, Optical Coherence</subject><subject>Toxoplasma - immunology</subject><subject>Toxoplasmosis</subject><subject>Toxoplasmosis, Ocular - epidemiology</subject><subject>Toxoplasmosis, Ocular - immunology</subject><subject>Toxoplasmosis, Ocular - parasitology</subject><subject>Uvea diseases</subject><subject>Uveitis</subject><subject>Uveitis - epidemiology</subject><subject>Uveitis - immunology</subject><subject>Uveitis - parasitology</subject><subject>vascularization</subject><subject>Vasculitis</subject><subject>Visual Acuity - physiology</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc2LFDEQxYMo7jh68i4NIgjaa1JJptMXQQa_YGEPKngL1enqNUtPMibd4v73pp1xXfXipQJ5v1S91GPsoeCngkvzgq7oFLiAUm6xlVDNptZKq9tsxVvNawD4fMLu5XzJeREbfpedAMiNMKpZsfPt6IN3OFZ7nCZKoYpDFd08Yqqm-D3uR8y7mH2upkQ4UV_5UGGVaKCUyitHoQjL5QdKncf77M6AY6YHx3PNPr15_XH7rj47f_t---qsdpq3U22URACS0pi-FT1K47gGFKYDqYXRQMNgdOcaEL1yHQdjwChwjZKCu76Va_by0Hc_dzvqf9rA0e6T32G6shG9_VMJ_ou9iN-sLP251qXB02ODFL_OlCe789nROGKgOGcrykwOUijzH6iARum2mFuzx3-hl3FOoWxioUQrteSbQj07UC7FnMsur30LbpdMbcnULpmWUuhHN796zf4KsQBPjgDmkuSQMDiff3PaGMX1srPnBy4XKVxQumnu37k_AJxvtyY</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>KOVACEVIC-PAVICEVIC, D</creator><creator>RADOSAVLJEVIC, A</creator><creator>ILIC, A</creator><creator>KOVACEVIC, I</creator><creator>DJURKOVIC-DJAKOVIC, O</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>M7N</scope><scope>5PM</scope></search><sort><creationdate>20120501</creationdate><title>Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia</title><author>KOVACEVIC-PAVICEVIC, D ; RADOSAVLJEVIC, A ; ILIC, A ; KOVACEVIC, I ; DJURKOVIC-DJAKOVIC, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-843a22e3388d91da38c052a18b2351852eff85bc721d4cb02882842c74310cd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>692/699</topic><topic>692/699/255/1715</topic><topic>692/700/478/174</topic><topic>Acuity</topic><topic>Adult</topic><topic>Antibodies, Protozoan - blood</topic><topic>Antiprotozoal Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blindness</topic><topic>Cataracts</topic><topic>Choroidal Neovascularization - epidemiology</topic><topic>Choroidal Neovascularization - immunology</topic><topic>Choroidal Neovascularization - parasitology</topic><topic>Clinical Study</topic><topic>Edema</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Eye</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Glaucoma</topic><topic>Glaucoma - epidemiology</topic><topic>Glaucoma - immunology</topic><topic>Glaucoma - parasitology</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulin M - blood</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>medical records</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Parasitic diseases</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Protozoal diseases</topic><topic>Referral and Consultation</topic><topic>Retina</topic><topic>Retinal Detachment - epidemiology</topic><topic>Retinal Detachment - immunology</topic><topic>Retinal Detachment - parasitology</topic><topic>Retrospective Studies</topic><topic>Serbia - epidemiology</topic><topic>Serology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tomography, Optical Coherence</topic><topic>Toxoplasma - immunology</topic><topic>Toxoplasmosis</topic><topic>Toxoplasmosis, Ocular - epidemiology</topic><topic>Toxoplasmosis, Ocular - immunology</topic><topic>Toxoplasmosis, Ocular - parasitology</topic><topic>Uvea diseases</topic><topic>Uveitis</topic><topic>Uveitis - epidemiology</topic><topic>Uveitis - immunology</topic><topic>Uveitis - parasitology</topic><topic>vascularization</topic><topic>Vasculitis</topic><topic>Visual Acuity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOVACEVIC-PAVICEVIC, D</creatorcontrib><creatorcontrib>RADOSAVLJEVIC, A</creatorcontrib><creatorcontrib>ILIC, A</creatorcontrib><creatorcontrib>KOVACEVIC, I</creatorcontrib><creatorcontrib>DJURKOVIC-DJAKOVIC, O</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOVACEVIC-PAVICEVIC, D</au><au>RADOSAVLJEVIC, A</au><au>ILIC, A</au><au>KOVACEVIC, I</au><au>DJURKOVIC-DJAKOVIC, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>26</volume><issue>5</issue><spage>723</spage><epage>728</epage><pages>723-728</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><coden>EYEEEC</coden><abstract>Purpose
To analyze the clinical pattern of ocular toxoplasmosis (OT) in a referral centre in Serbia.
Patients and methods
The medical records of consecutive patients admitted for OT to the single referral centre for uveitis in Serbia between 2006 and 2010 were retrospectively analyzed. OT was diagnosed on the basis of typical fundus lesions and positive serology for Toxoplasma.
Results
In a total of 457 uveitis patients, OT was the third leading cause, with 59 patients (12.9%). Most OT cases (73%) were monocular. An active primary retinal lesion was observed in 36% and recurrent OT in 64% patients. Localization of lesions was central/paracentral (44%), juxtapapillar (27%), peripheral (19%), and multifocal (10%). Other ocular manifestations of inflammation included vitritis (44%), anterior uveitis (19%), and retinal vasculitis (10%). Complications included choroidal neovascularization in two and exudative retinal detachment with cataract, glaucoma, and cystoid macular oedema in one patient each. The detection of Toxoplasma-specific IgM antibodies in a single patient indicates a low rate of OT concomitant with acute infection. After treatment, the mean best-corrected visual acuity (BCVA) increased significantly. However, 14 (24%) patients ended up legally blind in the affected eye, of which 2 (3%) with bilateral blindness, all with a very poor BCVA (0.047±0.055) at presentation. Visual impairment and treatment outcome were both associated with central localization of lesions (
P
<0.0001 and
P
=0.006, respectively).
Conclusion
OT is a significant cause of posterior uveitis in Serbia. Patients should be aware of the recurring nature of OT and react immediately if symptoms occur.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22361847</pmid><doi>10.1038/eye.2012.20</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Eye (London), 2012-05, Vol.26 (5), p.723-728 |
| issn | 0950-222X 1476-5454 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | 692/699 692/699/255/1715 692/700/478/174 Acuity Adult Antibodies, Protozoan - blood Antiprotozoal Agents - therapeutic use Biological and medical sciences Blindness Cataracts Choroidal Neovascularization - epidemiology Choroidal Neovascularization - immunology Choroidal Neovascularization - parasitology Clinical Study Edema Enzyme-Linked Immunosorbent Assay Eye Female Fluorescein Angiography Glaucoma Glaucoma - epidemiology Glaucoma - immunology Glaucoma - parasitology Human protozoal diseases Humans Immunoglobulin G - blood Immunoglobulin M Immunoglobulin M - blood Infectious diseases Inflammation Laboratory Medicine Male medical records Medical sciences Medicine Medicine & Public Health Middle Aged Miscellaneous Ophthalmology Parasitic diseases Pharmaceutical Sciences/Technology Protozoal diseases Referral and Consultation Retina Retinal Detachment - epidemiology Retinal Detachment - immunology Retinal Detachment - parasitology Retrospective Studies Serbia - epidemiology Serology Surgery Surgical Oncology Tomography, Optical Coherence Toxoplasma - immunology Toxoplasmosis Toxoplasmosis, Ocular - epidemiology Toxoplasmosis, Ocular - immunology Toxoplasmosis, Ocular - parasitology Uvea diseases Uveitis Uveitis - epidemiology Uveitis - immunology Uveitis - parasitology vascularization Vasculitis Visual Acuity - physiology |
| title | Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia |
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