Isoniazid vs. Rifampin for Latent Tuberculosis Infection in Jail Inmates: Toxicity and Adherence

This open-label randomized trial compared isoniazid (9 months) to rifampin (4 months) on toxicity and completion in a jailed population with latent tuberculosis infection. Rifampin resulted in fewer elevated liver function tests (risk ratio [RR] 0.39, 95% confidence interval [CI] [0.18, 0.86]) and l...

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Veröffentlicht in:	Journal of Correctional Health Care 2012-04, Vol.18 (2), p.131-142
Hauptverfasser:	White, Mary C., Tulsky, Jacqueline P., Lee, Ju Ruey-Jiuan, Chen, Lisa, Goldenson, Joe, Spetz, Joanne, Kawamura, L. Masae
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antitubercular Agents - administration & dosage Antitubercular Agents - adverse effects Antitubercular Agents - therapeutic use Clinical trials Directly Observed Therapy Drug therapy Drugs Female Health care Humans Hypersensitivity Infection Isoniazid Isoniazid - administration & dosage Isoniazid - adverse effects Isoniazid - therapeutic use Latent Tuberculosis - drug therapy Liver Liver Function Tests Male Medication Adherence Mycobacterium Prisoners Prisons Rifampin Rifampin - administration & dosage Rifampin - adverse effects Rifampin - therapeutic use Socioeconomic Factors Toxicity Tuberculosis
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