p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

We show that loss of p85α inhibits the growth and maturation of mast cells, whereas loss of p85β enhances this process. Whereas restoring the expression of p85α in P85α−/− cells restores these functions, overexpression of p85β has the opposite effect. Consistently, overexpression of p85β in WT mast...

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Veröffentlicht in:	Blood 2012-04, Vol.119 (17), p.3951-3961
Hauptverfasser:	Krishnan, Subha, Mali, Raghuveer Singh, Ramdas, Baskar, Sims, Emily, Ma, Peilin, Ghosh, Joydeep, Munugalavadla, Veerendra, Hanneman, Philip, Beane, Joal D., Kapur, Reuben
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Cell Proliferation Class Ia Phosphatidylinositol 3-Kinase - physiology Enzyme-Linked Immunosorbent Assay Flow Cytometry Hematologic and hematopoietic diseases Hematopoiesis and Stem Cells Leukemia - etiology Leukemia - metabolism Leukemia - pathology Mast Cells - metabolism Mast Cells - pathology Medical sciences Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Mutation - genetics Myeloid Neoplasia Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Real-Time Polymerase Chain Reaction RNA, Messenger - genetics
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