Lysophosphatidic Acid Induces Lymphangiogenesis and IL-8 Production in Vitro in Human Lymphatic Endothelial Cells

The bioactive phospholipid lysophosphatidic acid (LPA) and its receptors LPA1-3 are aberrantly expressed in many types of human cancer. LPA has been reported to induce tumor cell proliferation, migration, and cytokine production. However, whether LPA exerts an effect on lymphatic endothelial cells (...

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Veröffentlicht in:	The American journal of pathology 2012-05, Vol.180 (5), p.2170-2181
Hauptverfasser:	Mu, Hong, Calderone, Tiffany L, Davies, Michael A, Prieto, Victor G, Wang, Hua, Mills, Gordon B, Bar-Eli, Menashe, Gershenwald, Jeffrey E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism Humans Interleukin-8 - biosynthesis Interleukin-8 - genetics Interleukin-8 - physiology Investigative techniques, diagnostic techniques (general aspects) Lymphangiogenesis - drug effects Lymphangiogenesis - physiology Lymphatic Metastasis Lymphatic Vessels - drug effects Lymphatic Vessels - metabolism Lysophospholipids - administration & dosage Lysophospholipids - pharmacology Medical sciences Melanoma - metabolism Melanoma - secondary NF-kappa B - metabolism Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Lysophosphatidic Acid - genetics Receptors, Lysophosphatidic Acid - physiology Regular RNA, Small Interfering - genetics Sentinel Lymph Node Biopsy Signal Transduction - drug effects Up-Regulation - drug effects
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