Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

The decline in hematopoietic function seen during aging involves a progressive reduction in the immune response and an increased incidence of myeloid malignancy, and has been linked to aging of hematopoietic stem cells (HSCs). The molecular mechanisms underlying HSC aging remain unclear. Here we dem...

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Veröffentlicht in:	Cell stem cell 2012-05, Vol.10 (5), p.520-530
Hauptverfasser:	Florian, Maria Carolina, Dörr, Karin, Niebel, Anja, Daria, Deidre, Schrezenmeier, Hubert, Rojewski, Markus, Filippi, Marie-Dominique, Hasenberg, Anja, Gunzer, Matthias, Scharffetter-Kochanek, Karin, Zheng, Yi, Geiger, Hartmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Aging, Premature - genetics Animals Biological and medical sciences cdc42 GTP-Binding Protein - metabolism cdc42 GTP-Binding Protein - pharmacology Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell Polarity - genetics Cells, Cultured Cellular Senescence Fundamental and applied biological sciences. Psychology GTPase-Activating Proteins - genetics Hematopoiesis - genetics Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - physiology Histones - metabolism Mice Mice, Knockout Molecular and cellular biology Myeloid Cells - physiology Protein Transport - genetics Rejuvenation Tubulin - metabolism
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