NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway

The AAA+ protein p97 and its UBA-UBX cofactors are thought to promote degradation by separating ubiquitinated proteins from membranes or protein complexes. UBA-UBX proteins can interact with cullin-RING ubiquitin ligases, and UBXD7 is now seen to specifically bind NEDD8 on active, neddylated cullins...

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Veröffentlicht in:	Nature structural & molecular biology 2012-05, Vol.19 (5), p.511-516
Hauptverfasser:	den Besten, Willem, Verma, Rati, Kleiger, Gary, Oania, Robert S, Deshaies, Raymond J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/474/2073 Adaptor Proteins, Signal Transducing Adenosine triphosphatase Adenosine Triphosphatases - metabolism Autophagy Biochemistry Biological Microscopy Biomedical and Life Sciences Carrier Proteins - chemistry Carrier Proteins - metabolism Cell Line Cullin Proteins - metabolism DNA-Binding Proteins - metabolism Humans Life Sciences Ligases Membrane Biology Models, Molecular NEDD8 Protein Nuclear Proteins - metabolism Physiological aspects Polycomb Repressive Complex 1 Protein Interaction Domains and Motifs Protein Interaction Maps Protein Structure Proteins Ubiquitin Ubiquitin - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitins - metabolism Yeast Yeasts
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