The dynamics of drug resistance: A mathematical perspective

Highlights ► We review the aspects of MDR that have been mathematically studied. ► We explain how mathematics can be used to study drug resistance. ► We demonstrate how mathematics can be used in combination with experimental and clinical tools.

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Bibliographische Detailangaben
Veröffentlicht in:	Drug resistance updates 2012-02, Vol.15 (1), p.90-97
Hauptverfasser:	Lavi, Orit, Gottesman, Michael M, Levy, Doron
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological Transport - drug effects Drug Administration Schedule Drug Resistance, Multiple Drug Resistance, Neoplasm Drug scheduling and sequencing Drug-dependent/independent resistance Evolution of resistance Hematology, Oncology and Palliative Medicine Humans Infectious Disease Mathematical Computing Mathematical modeling Models, Biological Multidrug resistance Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Protein Isoforms - antagonists & inhibitors Protein Isoforms - genetics Protein Isoforms - metabolism
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Beschreibung
Zusammenfassung:	Highlights ► We review the aspects of MDR that have been mathematically studied. ► We explain how mathematics can be used to study drug resistance. ► We demonstrate how mathematics can be used in combination with experimental and clinical tools.
ISSN:	1368-7646 1532-2084
DOI:	10.1016/j.drup.2012.01.003