Conditioned Aversion Study of Sucrose and SC45647 Taste in TRPM5 Knockout Mice

Previously, published studies have reported mixed results regarding the role of the TRPM5 cation channel in signaling sweet taste by taste sensory cells. Some studies have reported a complete loss of sweet taste preference in TRPM5 knockout (KO) mice, whereas others have reported only a partial loss...

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Veröffentlicht in:	Chemical senses 2012-06, Vol.37 (5), p.391-401
Hauptverfasser:	Eddy, Meghan C, Eschle, Benjamin K, Peterson, Darlene, Lauras, Nathan, Margolskee, Robert F, Delay, Eugene R
Format:	Artikel
Sprache:	eng
Schlagworte:	acetates Acetic acid Animals Aversion learning Biological and medical sciences Bitter taste cation channels Chemical stimuli Choice Behavior - drug effects Choice Behavior - physiology Conditioning (Psychology) - drug effects Dysgeusia - genetics Dysgeusia - physiopathology Flavor food choices Fundamental and applied biological sciences. Psychology Guanidines - administration & dosage learning Lithium Chloride - administration & dosage Mice Mice, Knockout Odor Odorants odors Olfaction. Taste Original Pentanols - administration & dosage Perception Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Sensory evaluation Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Smell - drug effects Smell - physiology Sucrose Sucrose - administration & dosage Sweet taste Sweetening Agents - administration & dosage taste Taste - drug effects Taste - physiology Taste aversion Taste Perception - drug effects Taste Perception - physiology transient receptor potential proteins TRPM Cation Channels - deficiency TRPM Cation Channels - genetics
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