Characterization of Tumor Angiogenesis in Rat Brain Using Iron-Based Vessel Size Index MRI in Combination with Gadolinium-Based Dynamic Contrast-Enhanced MRI
This study aimed at combining an iron-based, steady-state, vessel size index magnetic resonance imaging (VSI MRI) approach, and a gadolinium (Gd)-based, dynamic contrast-enhanced MRI approach (DCE MRI) to characterize tumoral microvasculature. Rats bearing an orthotopic glioma (C6, n=14 and RG2, n=6...
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| Veröffentlicht in: | Journal of cerebral blood flow and metabolism 2009-10, Vol.29 (10), p.1714-1726 |
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| creator | Beaumont, Marine Lemasson, Benjamin Farion, Régine Segebarth, Christoph Rémy, Chantal Barbier, Emmanuel L |
| description | This study aimed at combining an iron-based, steady-state, vessel size index magnetic resonance imaging (VSI MRI) approach, and a gadolinium (Gd)-based, dynamic contrast-enhanced MRI approach (DCE MRI) to characterize tumoral microvasculature. Rats bearing an orthotopic glioma (C6, n=14 and RG2, n=6) underwent DCE MRI and combined VSI and DCE MRI 4 h later, at 2.35 T. Gd-DOTA (200 μmol of Gd per kg) and ultrasmall superparamagnetic iron oxide (USPIO) (200 μmol of iron per kg) were used for DCE and VSI MRI, respectively. C6 and RG2 gliomas were equally permeable to Gd-DOTA but presented different blood volume fractions and VSI, in good agreement with histologic data. The presence of USPIO yielded reduced Ktrans values. The Ktrans values obtained with Gd-DOTA in the absence and in the presence of USPIO were well correlated for the C6 glioma but not for the RG2 glioma. It was also observed that, within the time frame of DCE MRI, USPIO remained intravascular in the C6 glioma whereas it extravasated in the RG2 glioma. In conclusion, VSI and DCE MRI can be combined provided that USPIO does not extravasate with the time frame of the DCE MRI experiment. The mechanisms at the origin of USPIO extravasation remain to be elucidated. |
| doi_str_mv | 10.1038/jcbfm.2009.86 |
| format | Article |
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Rats bearing an orthotopic glioma (C6, n=14 and RG2, n=6) underwent DCE MRI and combined VSI and DCE MRI 4 h later, at 2.35 T. Gd-DOTA (200 μmol of Gd per kg) and ultrasmall superparamagnetic iron oxide (USPIO) (200 μmol of iron per kg) were used for DCE and VSI MRI, respectively. C6 and RG2 gliomas were equally permeable to Gd-DOTA but presented different blood volume fractions and VSI, in good agreement with histologic data. The presence of USPIO yielded reduced Ktrans values. The Ktrans values obtained with Gd-DOTA in the absence and in the presence of USPIO were well correlated for the C6 glioma but not for the RG2 glioma. It was also observed that, within the time frame of DCE MRI, USPIO remained intravascular in the C6 glioma whereas it extravasated in the RG2 glioma. In conclusion, VSI and DCE MRI can be combined provided that USPIO does not extravasate with the time frame of the DCE MRI experiment. The mechanisms at the origin of USPIO extravasation remain to be elucidated.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1038/jcbfm.2009.86</identifier><identifier>PMID: 19584891</identifier><identifier>CODEN: JCBMDN</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Brain Neoplasms - blood supply ; Brain Neoplasms - diagnosis ; Cell Membrane Permeability ; Contrast Media ; Dextrans - pharmacokinetics ; Ferrosoferric Oxide - pharmacokinetics ; Gadolinium - pharmacokinetics ; Glioma - diagnosis ; Glioma - pathology ; Heterocyclic Compounds - pharmacokinetics ; Investigative techniques, diagnostic techniques (general aspects) ; Iron - pharmacokinetics ; Magnetic Resonance Imaging - methods ; Magnetite Nanoparticles ; Male ; Medical sciences ; Microvessels ; Neovascularization, Pathologic - diagnosis ; Nervous system ; Neurology ; Organometallic Compounds - pharmacokinetics ; Radiodiagnosis. 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Nmr spectrometry ; Rats ; Rats, Wistar ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Journal of cerebral blood flow and metabolism, 2009-10, Vol.29 (10), p.1714-1726</ispartof><rights>2009 ISCBFM</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Oct 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-7b50d742b506473d76cb6f1c483357dae412498e0456bb92082b933e318dcbc13</citedby><cites>FETCH-LOGICAL-c508t-7b50d742b506473d76cb6f1c483357dae412498e0456bb92082b933e318dcbc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2009.86$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1038/jcbfm.2009.86$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,777,781,882,21800,27905,27906,43602,43603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22115534$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19584891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beaumont, Marine</creatorcontrib><creatorcontrib>Lemasson, Benjamin</creatorcontrib><creatorcontrib>Farion, Régine</creatorcontrib><creatorcontrib>Segebarth, Christoph</creatorcontrib><creatorcontrib>Rémy, Chantal</creatorcontrib><creatorcontrib>Barbier, Emmanuel L</creatorcontrib><title>Characterization of Tumor Angiogenesis in Rat Brain Using Iron-Based Vessel Size Index MRI in Combination with Gadolinium-Based Dynamic Contrast-Enhanced MRI</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>This study aimed at combining an iron-based, steady-state, vessel size index magnetic resonance imaging (VSI MRI) approach, and a gadolinium (Gd)-based, dynamic contrast-enhanced MRI approach (DCE MRI) to characterize tumoral microvasculature. 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The mechanisms at the origin of USPIO extravasation remain to be elucidated.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - blood supply</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Cell Membrane Permeability</subject><subject>Contrast Media</subject><subject>Dextrans - pharmacokinetics</subject><subject>Ferrosoferric Oxide - pharmacokinetics</subject><subject>Gadolinium - pharmacokinetics</subject><subject>Glioma - diagnosis</subject><subject>Glioma - pathology</subject><subject>Heterocyclic Compounds - pharmacokinetics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iron - pharmacokinetics</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetite Nanoparticles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microvessels</subject><subject>Neovascularization, Pathologic - diagnosis</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Organometallic Compounds - pharmacokinetics</subject><subject>Radiodiagnosis. 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Nmr spectrometry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beaumont, Marine</creatorcontrib><creatorcontrib>Lemasson, Benjamin</creatorcontrib><creatorcontrib>Farion, Régine</creatorcontrib><creatorcontrib>Segebarth, Christoph</creatorcontrib><creatorcontrib>Rémy, Chantal</creatorcontrib><creatorcontrib>Barbier, Emmanuel L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cerebral blood flow and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beaumont, Marine</au><au>Lemasson, Benjamin</au><au>Farion, Régine</au><au>Segebarth, Christoph</au><au>Rémy, Chantal</au><au>Barbier, Emmanuel L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of Tumor Angiogenesis in Rat Brain Using Iron-Based Vessel Size Index MRI in Combination with Gadolinium-Based Dynamic Contrast-Enhanced MRI</atitle><jtitle>Journal of cerebral blood flow and metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>29</volume><issue>10</issue><spage>1714</spage><epage>1726</epage><pages>1714-1726</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><coden>JCBMDN</coden><abstract>This study aimed at combining an iron-based, steady-state, vessel size index magnetic resonance imaging (VSI MRI) approach, and a gadolinium (Gd)-based, dynamic contrast-enhanced MRI approach (DCE MRI) to characterize tumoral microvasculature. Rats bearing an orthotopic glioma (C6, n=14 and RG2, n=6) underwent DCE MRI and combined VSI and DCE MRI 4 h later, at 2.35 T. Gd-DOTA (200 μmol of Gd per kg) and ultrasmall superparamagnetic iron oxide (USPIO) (200 μmol of iron per kg) were used for DCE and VSI MRI, respectively. C6 and RG2 gliomas were equally permeable to Gd-DOTA but presented different blood volume fractions and VSI, in good agreement with histologic data. The presence of USPIO yielded reduced Ktrans values. The Ktrans values obtained with Gd-DOTA in the absence and in the presence of USPIO were well correlated for the C6 glioma but not for the RG2 glioma. It was also observed that, within the time frame of DCE MRI, USPIO remained intravascular in the C6 glioma whereas it extravasated in the RG2 glioma. In conclusion, VSI and DCE MRI can be combined provided that USPIO does not extravasate with the time frame of the DCE MRI experiment. The mechanisms at the origin of USPIO extravasation remain to be elucidated.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>19584891</pmid><doi>10.1038/jcbfm.2009.86</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cerebral blood flow and metabolism, 2009-10, Vol.29 (10), p.1714-1726 |
| issn | 0271-678X 1559-7016 |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Animals Biological and medical sciences Brain Neoplasms - blood supply Brain Neoplasms - diagnosis Cell Membrane Permeability Contrast Media Dextrans - pharmacokinetics Ferrosoferric Oxide - pharmacokinetics Gadolinium - pharmacokinetics Glioma - diagnosis Glioma - pathology Heterocyclic Compounds - pharmacokinetics Investigative techniques, diagnostic techniques (general aspects) Iron - pharmacokinetics Magnetic Resonance Imaging - methods Magnetite Nanoparticles Male Medical sciences Microvessels Neovascularization, Pathologic - diagnosis Nervous system Neurology Organometallic Compounds - pharmacokinetics Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Wistar Vascular diseases and vascular malformations of the nervous system |
| title | Characterization of Tumor Angiogenesis in Rat Brain Using Iron-Based Vessel Size Index MRI in Combination with Gadolinium-Based Dynamic Contrast-Enhanced MRI |
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