Glutamate Antagonists Limit Tumor Growth

Neuronal progenitors and tumor cells possess propensity to proliferate and to migrate. Glutamate regulates proliferation and migration of neurons during development, but it is not known whether it influences proliferation and migration of tumor cells. We demonstrate that glutamate antagonists inhibi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-05, Vol.98 (11), p.6372-6377
Hauptverfasser:	Rzeski, Wojciech, Turski, Lechoslaw, Ikonomidou, Chrysanthy
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anti-Anxiety Agents - pharmacology Antineoplastic Agents - pharmacology Benzodiazepines Biological Sciences Cell Division Cell growth Cell lines Cell Movement - drug effects Cells Cisplatin - pharmacology Cultured cells Cyclophosphamide - pharmacology Dizocilpine Maleate - pharmacology Drug Synergism Excitatory amino acid antagonists Excitatory Amino Acid Antagonists - pharmacology Glutamic Acid - physiology Growth Inhibitors - pharmacology HT29 Cells Humans Immunohistochemistry - methods Lungs Neoplasms - physiopathology Neurons Receptors, AMPA - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Stromal cells Thiotepa - pharmacology Thyroid cancer Tumor cell line Tumor Cells, Cultured Tumors Vinblastine - pharmacology
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