Prenatal Exposure to Polycyclic Aromatic Hydrocarbons, Benzo[a]pyrene-DNA Adducts, and Genomic DNA Methylation in Cord Blood

Background: Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic environmental pollutants generated during incomplete combustion. After exposure and during metabolism, PAHs can form reactive epoxides that can covalently bind to DNA. These PAH–DNA adducts are established markers of cancer risk. P...

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Veröffentlicht in:	Environmental health perspectives 2012-05, Vol.120 (5), p.733-738
Hauptverfasser:	Herbstman, Julie B., Tang, Deliang, Zhu, Deguang, Qu, Lirong, Sjödin, Andreas, Li, Zheng, Camann, David, Perera, Frederica P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Adult Benzo(a)pyrene Benzopyrene Biological and medical sciences Blood Cancer Carcinogenesis, carcinogens and anticarcinogens Chemical agents Children's Health Cord blood Deoxyribonucleic acid DNA DNA adducts DNA Adducts - blood DNA Methylation Environment. Living conditions Environmental health Female Fetal Blood Genomics Health aspects Humans Maternal Exposure Medical sciences Methylation New York City Physiological aspects Polyallylamine hydrochloride Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - blood Pregnancy Prenatal exposure Public health. Hygiene Public health. Hygiene-occupational medicine Rope Tobacco smoking Toxicology Tumors Urine
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