A Rab8 Guanine Nucleotide Exchange Factor-Effector Interaction Network Regulates Primary Ciliogenesis

Primary cilia are microtubule-based solitary membrane projections on the cell surface that play important roles in signaling and development. Recent studies have demonstrated that polarized vesicular trafficking involving the small GTPase Rab8 and its guanine nucleotide exchange factor Rabin8 is ess...

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Veröffentlicht in:	The Journal of biological chemistry 2012-05, Vol.287 (19), p.15602-15609
Hauptverfasser:	Feng, Shanshan, Knödler, Andreas, Ren, Jinqi, Zhang, Jian, Zhang, Xiaoyu, Hong, Yujuan, Huang, Shaohui, Peränen, Johan, Guo, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Biology Cell Line Cilia Cilia - genetics Cilia - metabolism Cilia - physiology Electrophoresis, Polyacrylamide Gel Endocytosis Exocyst Exocytosis Germinal Center Kinases Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism HeLa Cells Humans Microscopy, Fluorescence Mutation Protein Binding Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism Rab Proteins Rab11 Rab8 Rabin8 Receptor Recycling RNA Interference Sec15 Signal Transduction - genetics Signal Transduction - physiology
Online-Zugang:	Volltext
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