Lens Epithelium-derived Growth Factor/p75 Qualifies as a Target for HIV Gene Therapy in the NSG Mouse Model

Lens epithelium-derived growth factor (LEDGF/p75) is an essential cofactor of HIV integration. Both stable overexpression of the C-terminal part of LEDGF/p75 (LEDGF325–530) containing the integrase (IN)-binding domain (IBD) and stable knockdown (KD) of LEDGF/p75 are known to inhibit HIV infection in...

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Veröffentlicht in:	Molecular therapy 2012-05, Vol.20 (5), p.908-917
Hauptverfasser:	Vets, Sofie, Kimpel, Janine, Volk, Andreas, De Rijck, Jan, Schrijvers, Rik, Verbinnen, Bert, Maes, Wim, Von Laer, Dorothee, Debyser, Zeger, Gijsbers, Rik
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Animals CD4-Positive T-Lymphocytes - transplantation CD4-Positive T-Lymphocytes - virology Cells, Cultured Crystal structure Cytomegalovirus Disease Models, Animal Efficiency Gene Expression Gene therapy Genetic Therapy - methods Genetic Vectors Growth factors HIV HIV - physiology HIV Infections - genetics HIV Infections - therapy HIV Infections - virology Human immunodeficiency virus Humans Infections Injections, Intraperitoneal Intercellular Signaling Peptides and Proteins - genetics Lentivirus - genetics Localization Mice Mice, Transgenic Mutation Original Peptide Fragments - genetics Proteins Toxicity Transduction, Genetic Transplantation, Heterologous Vectors (Biology) Virus Integration - genetics Virus Replication - genetics
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