Microglial Cell Activation is a Source of Metalloproteinase Generation during Hemorrhagic Transformation

Hemorrhage and edema accompany evolving brain tissue injury after ischemic stroke. In patients, these events have been associated with metalloproteinase (MMP)-9 in plasma. Both the causes and cellular sources of MMP-9 generation in this setting have not been defined. MMP-2 and MMP-9 in nonhuman prim...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2012-05, Vol.32 (5), p.919-932
Hauptverfasser:	del Zoppo, Gregory J, Frankowski, Harald, Gu, Yu-Huan, Osada, Takashi, Kanazawa, Masato, Milner, Richard, Wang, Xiaoyun, Hosomi, Naohisa, Mabuchi, Takuma, Koziol, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - metabolism Astrocytes - pathology Biological and medical sciences Brain Edema - enzymology Brain Edema - pathology Brain Edema - physiopathology Brain injury Brain Ischemia - enzymology Brain Ischemia - pathology Brain Ischemia - physiopathology Cell activation Cell Hypoxia Cells, Cultured Cerebral blood flow Edema Enzyme Precursors - secretion Extravasation Fibronectin Fibronectins - metabolism Gelatinase A Gelatinase B Gelatinases - secretion Glucose Hemorrhage Humans Immunocytochemistry Injuries of the nervous system and the skull. Diseases due to physical agents Intracranial Hemorrhages - enzymology Intracranial Hemorrhages - pathology Intracranial Hemorrhages - physiopathology Ischemia Leakage Matrix Metalloproteinase 9 - secretion Medical sciences Metalloproteinase Mice Microglia Microglia - enzymology Microglia - pathology Neurology Original Papio anubis Polymerase chain reaction Primates Stroke Traumas. Diseases due to physical agents Vascular diseases and vascular malformations of the nervous system vitronectin Vitronectin - metabolism
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