Plateau distributions of DNA fragment lengths produced by extended light exposure of extranuclear photosensitizers in human cells

We have exploited properties of photosensitizers to study an aspect of the packing of chromatin in the cell nucleus. The fluorescent photosensitizers mesotetra(3-hydroxyphenyl) porphyrin and Photofrin II were both localized in the nuclear membrane and other membrane structures, but could not be foun...

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Veröffentlicht in:	Nucleic acids research 1992-12, Vol.20 (24), p.6687-6693
Hauptverfasser:	Kvam, Egil, Stokke, Trond, Moan, Johan, Steen, Harald B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological effects of radiation Cell Line DNA - drug effects DNA - isolation & purification DNA Probes Electrophoresis, Agar Gel Fundamental and applied biological sciences. Psychology Genes, fos Genes, myc Genes, p53 Humans Light Microscopy, Fluorescence Molecular Weight Oligodeoxyribonucleotides - isolation & purification Porphyrins - pharmacology Radiation-Sensitizing Agents - pharmacology Radiosensitizing agents. Photosensitizing agents. Thermosensitizing agents Tissues, organs and organisms biophysics
Online-Zugang:	Volltext
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