UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells

The cornea is highly sensitive to ultraviolet B (UVB) light-induced oxidative stress, a process that results in the production of inflammatory mediators which have been implicated in tissue injury. In the present studies, we characterized the inflammatory response of human corneal epithelial cells t...

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Veröffentlicht in:	Biochemical pharmacology 2011-04, Vol.81 (7), p.873-880
Hauptverfasser:	Black, Adrienne T., Gordon, Marion. K., Heck, Diane E., Gallo, Michael A., Laskin, Debra L., Laskin, Jeffrey D.
Format:	Artikel
Sprache:	eng
Schlagworte:	antioxidants Antioxidants - metabolism Base Sequence Biological and medical sciences biosynthesis Blotting, Western catalase cornea cytokines Cytokines - metabolism DNA Primers epithelial cells Epithelium, Corneal - cytology Epithelium, Corneal - metabolism Epithelium, Corneal - radiation effects gene expression General pharmacology glutathione heme oxygenase (biliverdin-producing) Humans inflammation Inflammation Mediators - metabolism Leukotrienes Medical sciences Miscellaneous mitogen-activated protein kinase Ocular Ophthalmology Oxidative Stress pharmacology Pharmacology. Drug treatments Polymerase Chain Reaction prostaglandin synthase Prostaglandins reactive oxygen species Reactive Oxygen Species - metabolism RNA, Messenger - genetics superoxide dismutase Ultraviolet light ultraviolet radiation Ultraviolet Rays
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