2-decenoic acid ethyl ester, a compound that elicits neurotrophin-like intracellular signals, facilitating functional recovery from cerebral infarction in mice

In our previous study, we found that trans-2-decenoic acid ethyl ester (DAEE), a derivative of a medium-chain fatty acid, elicits neurotrophin-like signals including the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in cultured mouse cortical neurons. Here, we examined the ef...

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Veröffentlicht in:	International journal of molecular sciences 2012-04, Vol.13 (4), p.4968-4981
Hauptverfasser:	Tanaka, Yoshitaka, Fukumitsu, Hidefumi, Soumiya, Hitomi, Yoshimura, Shinichi, Iwama, Toru, Furukawa, Shoei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animal models Animals Blood-Brain Barrier - drug effects Body weight Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cell survival Cerebral blood flow Cerebral Cortex - cytology Cerebral Cortex - pathology Cerebral infarction Cerebral Infarction - drug therapy Chi-square test Cortex Disease Models, Animal Esters Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Fatty acids Fatty Acids, Monounsaturated - chemistry Fatty Acids, Monounsaturated - therapeutic use Infarction, Middle Cerebral Artery - drug therapy Ischemia Kinases Male Medical prognosis Mice Mortality Nerve Growth Factors - metabolism Neurological diseases Neurological disorders Neuroprotective Agents - chemistry Neuroprotective Agents - therapeutic use Oxidative Stress - drug effects Paralysis Paralysis - prevention & control Phosphorylation Recovery of function Stroke Veins & arteries
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