Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon

Objective The RhoA/Rho kinase pathway plays a pivotal role in cold‐induced vasoconstriction, vascular smooth muscle cells function, and vascular homeostasis. This study evaluates the efficacy of fasudil, a RhoA/Rho kinase inhibitor, to reverse cold‐induced vasospasm in patients with Raynaud's p...

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Veröffentlicht in:	Arthritis care & research (2010) 2012-06, Vol.64 (6), p.925-929
Hauptverfasser:	Fava, Andrea, Wung, Peter K., Wigley, Fredrick M., Hummers, Laura K., Daya, Natalie R., Ghazarian, Sharon R., Boin, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - administration & dosage 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use Administration, Oral Adult Aged Cross-Over Studies Double-Blind Method Female Humans Male Middle Aged Raynaud Disease - drug therapy Raynaud Disease - etiology Regional Blood Flow - drug effects rho-Associated Kinases - antagonists & inhibitors Scleroderma, Systemic - complications Skin - blood supply Skin Temperature - drug effects Treatment Outcome
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