CTCF-binding elements mediate control of V(D)J recombination

Immunoglobulin heavy chain (IgH) variable region exons are assembled from V H , D and J H gene segments in developing B lymphocytes. Within the 2.7-megabase mouse Igh locus, V(D)J recombination is regulated to ensure specific and diverse antibody repertoires. Here we report in mice a key Igh V(D)J r...

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Veröffentlicht in:	Nature (London) 2011-09, Vol.477 (7365), p.424-430
Hauptverfasser:	Guo, Chunguang, Yoon, Hye Suk, Franklin, Andrew, Jain, Suvi, Ebert, Anja, Cheng, Hwei-Ling, Hansen, Erica, Despo, Orion, Bossen, Claudia, Vettermann, Christian, Bates, Jamie G., Richards, Nicholas, Myers, Darienne, Patel, Harin, Gallagher, Michael, Schlissel, Mark S., Murre, Cornelis, Busslinger, Meinrad, Giallourakis, Cosmas C., Alt, Frederick W.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2152/2497 Animal care Animals B-Lymphocytes - cytology B-Lymphocytes - metabolism Binding sites Biological and medical sciences CCCTC-Binding Factor Cell Lineage - genetics Chromosomes, Mammalian - genetics Chromosomes, Mammalian - metabolism Deoxyribonucleic acid DNA DNA, Intergenic - genetics Enhancer Elements, Genetic - genetics Feedback, Physiological Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Rearrangement, B-Lymphocyte, Heavy Chain - genetics Genes Genetics of the immune response Germ Cells - metabolism Humanities and Social Sciences Immunobiology Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Lymphocytes Mice multidisciplinary Mutation - genetics Recombination, Genetic - genetics Regulatory Sequences, Nucleic Acid - genetics Repressor Proteins - metabolism Science Science (multidisciplinary) T cell receptors Thymus Gland - cytology Transcription, Genetic - genetics VDJ Exons - genetics
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