Defect of Adaptation to Hypoxia in Patients With COPD Due to Reduction of Histone Deacetylase 7

Background Hypoxia inducible factor (HIF)-1 plays an important role in cellular adaptation to hypoxia by activating oxygen-regulated genes such as vascular endothelial growth factor (VEGF) and erythropoietin. Sputum VEGF levels are reported to be decreased in COPD, despite hypoxia. Here we show that...

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Veröffentlicht in:	Chest 2012-05, Vol.141 (5), p.1233-1242
Hauptverfasser:	To, Masako, MD, PhD, Yamamura, Satoshi, PhD, Akashi, Kenichi, MD, PhD, Charron, Catherine E., PhD, Haruki, Kosuke, MD, PhD, MTropMed, Barnes, Peter J., DM, DSc, FCCP, Ito, Kazuhiro, DVM, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide Adaptation, Physiological - genetics Adaptations Aged Biological and medical sciences Carbon dioxide Cardiology. Vascular system Cell Hypoxia - genetics Cells, Cultured Chest Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Erythropoietin Erythropoietin - genetics Female Gel electrophoresis Gene Expression - genetics Histone deacetylase Histone Deacetylases - deficiency Histone Deacetylases - genetics Humans Hypoxia Hypoxia - genetics Hypoxia - physiopathology Hypoxia-inducible factor 1 alpha Hypoxia-Inducible Factor 1, alpha Subunit - genetics Male Medical sciences Middle Aged Monocytes - metabolism mRNA Nuclear transport Original Research Oxygen Peripheral blood mononuclear cells Pneumology Polymerase chain reaction Promoter Regions, Genetic - genetics Promoters Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary/Respiratory RNA, Messenger - genetics Sputum Statistics as Topic Transcriptional Activation - genetics Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Western blotting
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