Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges

Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges

Acute kidney injury (AKI) is strongly associated with increased morbidity and mortality in critically ill patients. Efforts to change its clinical course have failed because clinically available therapeutic measures are currently lacking, and early detection is impossible with serum creatinine (SCr)...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical kidney journal 2012-04, Vol.5 (2), p.102-108
Hauptverfasser: de Geus, Hilde R. H., Betjes, Michiel G., Bakker, Jan
Format: Artikel
Sprache:eng
Schlagworte:
Original Contributions
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 108
container_issue 2
container_start_page 102
container_title Clinical kidney journal
container_volume 5
creator de Geus, Hilde R. H.
Betjes, Michiel G.
Bakker, Jan
description Acute kidney injury (AKI) is strongly associated with increased morbidity and mortality in critically ill patients. Efforts to change its clinical course have failed because clinically available therapeutic measures are currently lacking, and early detection is impossible with serum creatinine (SCr). The demand for earlier markers has prompted the discovery of several candidates to serve this purpose. In this paper, we review available biomarker studies on the early predictive performance in developing AKI in adult critically ill patients. We make an effort to present the results from the perspective of possible clinical utility.
doi_str_mv 10.1093/ckj/sfs008
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3341843</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ckj/sfs008</oup_id><sourcerecordid>1826558115</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-ae783421b19470b3563703b08ec291a0b36aa3dcdf571a1ea74cd14717ed75f3</originalsourceid><addsrcrecordid>eNp9kU1rGzEQhkVpSUKSS35A0aVQCm6klWTJPRTSkLaBQC-5i7F2Npa9lrb6cPG_r4JT0146lxlmHt6Z4SXkirOPnC3Etdusr_OQGTOvyFnHpJkZxcXrY83UKbnMec1atAmT6oScdp0RwjB9RqYvPm4hbTBlOsREywrplLD3rvgYaBwouFqQbnwfcE99WNe0_0SBBkgJit8hTbjz-Is22tWUMBSaC5SaKYSeDrXUhNStYBwxPGG-IG8GGDNevuRz8vj17vH2--zhx7f725uHmZNalhmgNkJ2fMkXUrOlUHOhmVgyg65bcGidOYDoXT8ozYEjaOl6LjXX2Gs1iHPy-SA71eUWe9fOSjDaKfn27d5G8PbfSfAr-xR3VgjJjRRN4P2LQIo_K-Zitz47HEcIGGu23HRzpQznqqEfDqhLMeeEw3ENZ_bZJNtMsgeTGvz278OO6B9LGvDuAMQ6_U_oNx-9nWo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826558115</pqid></control><display><type>article</type><title>Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges</title><source>OUP_牛津大学出版社OA刊</source><source>NCBI_PubMed Central（免费）</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>de Geus, Hilde R. H. ; Betjes, Michiel G. ; Bakker, Jan</creator><creatorcontrib>de Geus, Hilde R. H. ; Betjes, Michiel G. ; Bakker, Jan</creatorcontrib><description>Acute kidney injury (AKI) is strongly associated with increased morbidity and mortality in critically ill patients. Efforts to change its clinical course have failed because clinically available therapeutic measures are currently lacking, and early detection is impossible with serum creatinine (SCr). The demand for earlier markers has prompted the discovery of several candidates to serve this purpose. In this paper, we review available biomarker studies on the early predictive performance in developing AKI in adult critically ill patients. We make an effort to present the results from the perspective of possible clinical utility.</description><identifier>ISSN: 2048-8505</identifier><identifier>EISSN: 2048-8513</identifier><identifier>DOI: 10.1093/ckj/sfs008</identifier><identifier>PMID: 22833807</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Original Contributions</subject><ispartof>Clinical kidney journal, 2012-04, Vol.5 (2), p.102-108</ispartof><rights>The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ae783421b19470b3563703b08ec291a0b36aa3dcdf571a1ea74cd14717ed75f3</citedby><cites>FETCH-LOGICAL-c474t-ae783421b19470b3563703b08ec291a0b36aa3dcdf571a1ea74cd14717ed75f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341843/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341843/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1604,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22833807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Geus, Hilde R. H.</creatorcontrib><creatorcontrib>Betjes, Michiel G.</creatorcontrib><creatorcontrib>Bakker, Jan</creatorcontrib><title>Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges</title><title>Clinical kidney journal</title><addtitle>Clin Kidney J</addtitle><description>Acute kidney injury (AKI) is strongly associated with increased morbidity and mortality in critically ill patients. Efforts to change its clinical course have failed because clinically available therapeutic measures are currently lacking, and early detection is impossible with serum creatinine (SCr). The demand for earlier markers has prompted the discovery of several candidates to serve this purpose. In this paper, we review available biomarker studies on the early predictive performance in developing AKI in adult critically ill patients. We make an effort to present the results from the perspective of possible clinical utility.</description><subject>Original Contributions</subject><issn>2048-8505</issn><issn>2048-8513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kU1rGzEQhkVpSUKSS35A0aVQCm6klWTJPRTSkLaBQC-5i7F2Npa9lrb6cPG_r4JT0146lxlmHt6Z4SXkirOPnC3Etdusr_OQGTOvyFnHpJkZxcXrY83UKbnMec1atAmT6oScdp0RwjB9RqYvPm4hbTBlOsREywrplLD3rvgYaBwouFqQbnwfcE99WNe0_0SBBkgJit8hTbjz-Is22tWUMBSaC5SaKYSeDrXUhNStYBwxPGG-IG8GGDNevuRz8vj17vH2--zhx7f725uHmZNalhmgNkJ2fMkXUrOlUHOhmVgyg65bcGidOYDoXT8ozYEjaOl6LjXX2Gs1iHPy-SA71eUWe9fOSjDaKfn27d5G8PbfSfAr-xR3VgjJjRRN4P2LQIo_K-Zitz47HEcIGGu23HRzpQznqqEfDqhLMeeEw3ENZ_bZJNtMsgeTGvz278OO6B9LGvDuAMQ6_U_oNx-9nWo</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>de Geus, Hilde R. H.</creator><creator>Betjes, Michiel G.</creator><creator>Bakker, Jan</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120401</creationdate><title>Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges</title><author>de Geus, Hilde R. H. ; Betjes, Michiel G. ; Bakker, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ae783421b19470b3563703b08ec291a0b36aa3dcdf571a1ea74cd14717ed75f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Original Contributions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Geus, Hilde R. H.</creatorcontrib><creatorcontrib>Betjes, Michiel G.</creatorcontrib><creatorcontrib>Bakker, Jan</creatorcontrib><collection>OUP_牛津大学出版社OA刊</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical kidney journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Geus, Hilde R. H.</au><au>Betjes, Michiel G.</au><au>Bakker, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges</atitle><jtitle>Clinical kidney journal</jtitle><addtitle>Clin Kidney J</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>5</volume><issue>2</issue><spage>102</spage><epage>108</epage><pages>102-108</pages><issn>2048-8505</issn><eissn>2048-8513</eissn><abstract>Acute kidney injury (AKI) is strongly associated with increased morbidity and mortality in critically ill patients. Efforts to change its clinical course have failed because clinically available therapeutic measures are currently lacking, and early detection is impossible with serum creatinine (SCr). The demand for earlier markers has prompted the discovery of several candidates to serve this purpose. In this paper, we review available biomarker studies on the early predictive performance in developing AKI in adult critically ill patients. We make an effort to present the results from the perspective of possible clinical utility.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>22833807</pmid><doi>10.1093/ckj/sfs008</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2048-8505
ispartof Clinical kidney journal, 2012-04, Vol.5 (2), p.102-108
issn 2048-8505
2048-8513
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3341843
source OUP_牛津大学出版社OA刊; NCBI_PubMed Central（免费）; EZB-FREE-00999 freely available EZB journals
subjects Original Contributions
title Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T06%3A45%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biomarkers%20for%20the%20prediction%20of%20acute%20kidney%20injury:%20a%20narrative%20review%20on%20current%20status%20and%20future%20challenges&rft.jtitle=Clinical%20kidney%20journal&rft.au=de%20Geus,%20Hilde%20R.%20H.&rft.date=2012-04-01&rft.volume=5&rft.issue=2&rft.spage=102&rft.epage=108&rft.pages=102-108&rft.issn=2048-8505&rft.eissn=2048-8513&rft_id=info:doi/10.1093/ckj/sfs008&rft_dat=%3Cproquest_pubme%3E1826558115%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1826558115&rft_id=info:pmid/22833807&rft_oup_id=10.1093/ckj/sfs008&rfr_iscdi=true