Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and difficult to diagnosis until late stages, the 5-y survival rate is around 5%. The identification of molecular cancer drivers is critical for furthering our understanding of t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-04, Vol.109 (16), p.5934-5941
Hauptverfasser:	Mann, Karen M., Ward, Jerrold M., Yew, Christopher Chin Kuan, Kovochich, Anne, Dawson, David W., Black, Michael A., Brett, Benjamin T., Sheetz, Todd E., Dupuy, Adam J., Chang, David K., Biankin, Andrew V., Waddell, Nicola, Kassahn, Karin S., Grimmond, Sean M., Rust, Alistair G., Adams, David J., Jenkins, Nancy A., Copeland, Neal G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology alleles Animals Biological Sciences Cancer Catenins Catenins - genetics Catenins - metabolism chromatin Disease Models, Animal DNA Transposable Elements DNA Transposable Elements - genetics Gene loci Genes Genes, ras Genes, ras - genetics Genetic mutation Genetic Predisposition to Disease Genetic Predisposition to Disease - genetics Genetic screening genetics Genome-Wide Association Study Genomes GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits - genetics GTP-Binding Protein alpha Subunits - metabolism GTP-Binding Protein alpha Subunits, Gq-G11 Humans Immunohistochemistry loci metabolism metastasis Mice Mice, 129 Strain Mice, Transgenic Mutagenesis Mutagenesis, Insertional mutagenicity Mutation Oncogenes Pancreas Pancreas - metabolism Pancreas - pathology Pancreatic cancer Pancreatic neoplasms Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology pathology patients point mutation Rodents Signal Transduction Signal Transduction - genetics statistical analysis Survival Analysis survival rate therapeutics Transposons Tumors
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