Lack of significant de novo HLA allosensitization in ventricular assist device recipients transfused with leukoreduced, ABO identical blood products
Abstract Ventricular assist devices provide support for a failing heart and often serve as a bridge to transplantation. The use of these devices has also been associated with allosensitization to HLA antigens because of transfusion of blood products. Our program established a protocol mandating the...
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| Veröffentlicht in: | Human immunology 2009-06, Vol.70 (6), p.413-416 |
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| creator | Coppage, Myra Baker, Marc Fialkow, Lawrence Meehan, Danielle Gettings, Kelly Chen, Leway Massey, H. Todd Blumberg, Neil |
| description | Abstract Ventricular assist devices provide support for a failing heart and often serve as a bridge to transplantation. The use of these devices has also been associated with allosensitization to HLA antigens because of transfusion of blood products. Our program established a protocol mandating the use of leukoreduced, irradiated and ABO identical products, including platelets, in patients receiving initial implantations of VADs as a bridge to transplantation. Recipients were tested for anti-HLA antibodies before VAD implantation and monthly post-implantation by cytotoxicity and solid phase assays. We observed minimal de novo anti-HLA sensitization (50%). In conclusion, The use of leukoreduced, irradiated, ABO identical blood products abrogates broad allosensitization in this highly transfused population. |
| doi_str_mv | 10.1016/j.humimm.2009.03.001 |
| format | Article |
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Todd ; Blumberg, Neil</creator><creatorcontrib>Coppage, Myra ; Baker, Marc ; Fialkow, Lawrence ; Meehan, Danielle ; Gettings, Kelly ; Chen, Leway ; Massey, H. Todd ; Blumberg, Neil</creatorcontrib><description>Abstract Ventricular assist devices provide support for a failing heart and often serve as a bridge to transplantation. The use of these devices has also been associated with allosensitization to HLA antigens because of transfusion of blood products. Our program established a protocol mandating the use of leukoreduced, irradiated and ABO identical products, including platelets, in patients receiving initial implantations of VADs as a bridge to transplantation. Recipients were tested for anti-HLA antibodies before VAD implantation and monthly post-implantation by cytotoxicity and solid phase assays. We observed minimal de novo anti-HLA sensitization (<10%) in this population of 55 patients, each receiving a mean of 90 blood components, using this approach. No patient developed broad sensitization (PRA>50%). In conclusion, The use of leukoreduced, irradiated, ABO identical blood products abrogates broad allosensitization in this highly transfused population.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/j.humimm.2009.03.001</identifier><identifier>PMID: 19275923</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ABO Blood-Group System - immunology ; ABO matching ; Adult ; Aged ; Allergy and Immunology ; Allosensitization ; Blood Transfusion ; Female ; Heart Transplantation ; Heart-Assist Devices ; HLA Antigens - immunology ; Humans ; Isoantibodies - blood ; Leukocyte Reduction Procedures ; Leukocytes - immunology ; Male ; Middle Aged ; PRA ; WBC reduction</subject><ispartof>Human immunology, 2009-06, Vol.70 (6), p.413-416</ispartof><rights>American Society for Histocompatibility and Immunogenetics</rights><rights>2009 American Society for Histocompatibility and Immunogenetics</rights><rights>2009 American Society for Histocompatibility and Immunogenetics. 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All rights reserved. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-2e374a7d0ece54ca4fab6b199495f9a0dddd3020949b063549ebae2c18bbc16e3</citedby><cites>FETCH-LOGICAL-c547t-2e374a7d0ece54ca4fab6b199495f9a0dddd3020949b063549ebae2c18bbc16e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0198885909000561$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19275923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coppage, Myra</creatorcontrib><creatorcontrib>Baker, Marc</creatorcontrib><creatorcontrib>Fialkow, Lawrence</creatorcontrib><creatorcontrib>Meehan, Danielle</creatorcontrib><creatorcontrib>Gettings, Kelly</creatorcontrib><creatorcontrib>Chen, Leway</creatorcontrib><creatorcontrib>Massey, H. Todd</creatorcontrib><creatorcontrib>Blumberg, Neil</creatorcontrib><title>Lack of significant de novo HLA allosensitization in ventricular assist device recipients transfused with leukoreduced, ABO identical blood products</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>Abstract Ventricular assist devices provide support for a failing heart and often serve as a bridge to transplantation. The use of these devices has also been associated with allosensitization to HLA antigens because of transfusion of blood products. Our program established a protocol mandating the use of leukoreduced, irradiated and ABO identical products, including platelets, in patients receiving initial implantations of VADs as a bridge to transplantation. Recipients were tested for anti-HLA antibodies before VAD implantation and monthly post-implantation by cytotoxicity and solid phase assays. We observed minimal de novo anti-HLA sensitization (<10%) in this population of 55 patients, each receiving a mean of 90 blood components, using this approach. No patient developed broad sensitization (PRA>50%). In conclusion, The use of leukoreduced, irradiated, ABO identical blood products abrogates broad allosensitization in this highly transfused population.</description><subject>ABO Blood-Group System - immunology</subject><subject>ABO matching</subject><subject>Adult</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Allosensitization</subject><subject>Blood Transfusion</subject><subject>Female</subject><subject>Heart Transplantation</subject><subject>Heart-Assist Devices</subject><subject>HLA Antigens - immunology</subject><subject>Humans</subject><subject>Isoantibodies - blood</subject><subject>Leukocyte Reduction Procedures</subject><subject>Leukocytes - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>PRA</subject><subject>WBC reduction</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks-O0zAQxiMEYsvCGyDkEydaxnH--YJUVsAiVdoDcLYcZ7Kd1rGLnRQtz8ED46gVC1zWF8uab76Z8W-y7CWHFQdevd2tttNAw7DKAeQKxAqAP8oWvKnlkvOqepwtgMtm2TSlvMiexbgDgBrq4ml2wWVelzIXi-zXRps98z2LdOuoJ6PdyDpkzh89u96smbbWR3SRRvqpR_KOkWNHdGMgM1kdmI6R4pxzJIMsoKEDpXBkY9Au9lPEjv2gccssTnsfsJsMdm_Y-v0Noy4JU0nLWut9xw7Bp-gYn2dPem0jvjjfl9m3jx--Xl0vNzefPl-tN0tTFvW4zFHUha47QINlYXTR67ZquZSFLHupoUtHQA7p3UIlykJiqzE3vGlbwysUl9m7k-9hagfszDyVtuoQaNDhTnlN6t-Io6269UclRAGS82Tw-mwQ_PcJ46gGigat1Q79FFVVC543pXhQmEOVc5HLJCxOQhN8jAH7P91wUDN3tVMn7mrmrkCoxD2lvfp7kvukM-j7UTH955EwqGgSpoSCErJRdZ4eqvC_gbHkZnh7vMO481NwiZXiKuYK1Jd59-bVA5nWrqy4-A0xP9r1</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Coppage, Myra</creator><creator>Baker, Marc</creator><creator>Fialkow, Lawrence</creator><creator>Meehan, Danielle</creator><creator>Gettings, Kelly</creator><creator>Chen, Leway</creator><creator>Massey, H. 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Recipients were tested for anti-HLA antibodies before VAD implantation and monthly post-implantation by cytotoxicity and solid phase assays. We observed minimal de novo anti-HLA sensitization (<10%) in this population of 55 patients, each receiving a mean of 90 blood components, using this approach. No patient developed broad sensitization (PRA>50%). In conclusion, The use of leukoreduced, irradiated, ABO identical blood products abrogates broad allosensitization in this highly transfused population.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19275923</pmid><doi>10.1016/j.humimm.2009.03.001</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Human immunology, 2009-06, Vol.70 (6), p.413-416 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ABO Blood-Group System - immunology ABO matching Adult Aged Allergy and Immunology Allosensitization Blood Transfusion Female Heart Transplantation Heart-Assist Devices HLA Antigens - immunology Humans Isoantibodies - blood Leukocyte Reduction Procedures Leukocytes - immunology Male Middle Aged PRA WBC reduction |
| title | Lack of significant de novo HLA allosensitization in ventricular assist device recipients transfused with leukoreduced, ABO identical blood products |
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