SOD1 suppresses maternal hyperglycemia-increased iNOS expression and consequent nitrosative stress in diabetic embryopathy

Objective Hyperglycemia induces oxidative stress and increases inducible nitric oxide synthase (iNOS) expression. We hypothesized that oxidative stress is responsible for hyperglycemia-induced iNOS expression. Study Design iNOS-luciferase activities, nitrosylated protein, and lipid peroxidation mark...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2012-05, Vol.206 (5), p.448.e1-448.e7
Hauptverfasser:	Weng, Hongbo, PhD, Li, Xuezheng, PhD, Reece, E. Albert, MD, MBA, PhD, Yang, Peixin, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers - metabolism Blotting, Western Cells, Cultured copper zinc superoxide dismutase 1 transgenic mice diabetic embryopathy Embryo, Mammalian - metabolism Female Fetal Diseases - etiology Fetal Diseases - metabolism Free Radical Scavengers - metabolism Free Radical Scavengers - pharmacology Hyperglycemia - complications Hyperglycemia - metabolism inducible nitric oxide synthase Mice Mice, Inbred C57BL Nitric Oxide Synthase Type II - metabolism nitrosative stress Obstetrics and Gynecology oxidative stress Oxidative Stress - drug effects Pregnancy Pregnancy in Diabetics - metabolism Real-Time Polymerase Chain Reaction Superoxide Dismutase - metabolism Superoxide Dismutase - pharmacology Superoxide Dismutase-1 Yolk Sac - cytology Yolk Sac - metabolism
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